Effects of cadmium on growth, sexual development, and metabolism in female rats

Journal Article · Tue Mar 01 00:00:00 EST 1977 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:7316450

Der, R; Fahim, Z; Yousef, M; Fahim, M

Female rats were exposed to cadmium by multiple intramuscular injections of 250 ..mu..g CaCl/sub 2/ for 54 days. Activity and haircoat were affected, sores on the sites of injection and persistent diestrus were observed in the treated rats. Morphological examination of organs revealed a smaller weight and size in reproductive organs and pituitary, but enlargement of liver, spleen, and kidney. The resistance to cadmium toxicity in female rats may be due to the elevated hepatic enzymatic demethylation activity.

• Research Organization: Univ. of Missouri, Columbia
• OSTI ID: 7316450
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 16:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
CADMIUM CHLORIDES
FEMALES
GONADS
GROWTH
HAIR
INTRAMUSCULAR INJECTION
KIDNEYS
LIVER
METABOLISM
METHYLATION
MORPHOLOGICAL CHANGES
ORGANS
PITUITARY GLAND
RATS
REPRODUCTION
SEX
SIZE
SPLEEN
TOXICITY
WEIGHT
ANIMALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHEMICAL REACTIONS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
METALS
RODENTS
SKIN
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)