Effects of ozone on the respiratory epithelium and alveolar macrophages of mice. I. Interferon production

Journal Article · Thu Jan 01 00:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-152-39423· OSTI ID:7312009

Ibrahim, A L; Zee, Y C; Osebold, J W

The effects of 0.8 ppM ozone on the capacity of the tracheal epithelium and alveolar macrophages of mice to produce interferon in vitro was studied. Exposure of mice to ozone for a period of 11 days or more affected the capacity of the tracheal epithelial cells in vitro to produce interferon. The inability of the tracheal epithelium in vitro to produce interferon was not due to the inhibition in the release of intracellular interferon but to an inhibition in the production of interferon. There was a complete recovery of the ability of tracheal epithelium to respond to interferon inducers after the mice were returned to ambient air 24 days post ozone exposure. However, ozone did not seem to have any affect on the capacity of the alveolar macrophages to produce interferon in vitro.

• Research Organization: Univ. of California, Davis
• OSTI ID: 7312009
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 152
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
BIOLOGICAL EFFECTS
BIOSYNTHESIS
EPITHELIUM
IN VITRO
INTERFERON
LUNGS
MACROPHAGES
MICE
MUCOUS MEMBRANES
RESPIRATORY SYSTEM
ANIMAL CELLS
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
MAMMALS
ORGANS
PHAGOCYTES
RODENTS
SOMATIC CELLS
SYNTHESIS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)