Linkage of mercury, cadmium, and arsenate and drug resistance in clinical isolates of Pseudomonas aeruginosa
- Jikei Univ., Tokyo
Many bacterial isolates are resistant to heavy metal ions. It is of interest that resistance to metals is mediated by the same plasmid that determines resistance to drugs. In the study, both metal and drug resistances were assayed in 787 pseudomonas aeruginosa isolates from clinical lesions, and an attempt was made to demonstrate a relation between the two phenomena. The four metals tested (Hg, Cd, As, and Pb) were provided as HgCl/sub 2/, CdCl/sub 2/, Na/sub 2/HAsO/sub 4/, and Pb(CH/sub 3/COO)/sub 2/, respectively. Of the 787 isolates, 99.8% were metal resistant, with most (99.5%) showing multiple resistance. Fifty-three percent of the isolates were both metal and drug resistant, whereas only 19% were metal resistant and drug sensitive.
- OSTI ID:
- 7282053
- Journal Information:
- Appl. Environ. Microbiol.; (United States), Vol. 33:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ARSENATES
BIOLOGICAL EFFECTS
BACTERIA
BIOLOGICAL ADAPTATION
CADMIUM
DRUGS
LEAD
MERCURY
METALS
PSEUDOMONAS
SENSITIVITY
ARSENIC COMPOUNDS
ELEMENTS
MICROORGANISMS
OXYGEN COMPOUNDS
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
550700 - Microbiology
550400 - Genetics