Biliary excretion of cadmium in rat. II. The role of metallothionein in the hepatobiliary transport of cadmium. [/sup 109/Cd]
Intravenous injection of /sup 109/Cd-labeled CdCl/sub 2/ (1 mg/kg) to control rats and rats that had been injected with CdCl/sub 2/ (0.25 mg/kg) 24 hr earlier showed that there was a decrease in the biliary excretion of /sup 109/Cd in the latter group. The 24 hr pretreatment with CdCl/sub 2/ resulted in induced synthesis of metallothionein in rat liver and kidney. The binding of cadmium to liver tissue was increased and the renal accumulation of cadmium was unaltered on cadmium pretreatment. Rat liver metallothionein was isolated from rats injected repeatedly with CdCl/sub 2/. Intravenous injection of cadmium-bound metallothionein gave a different distribution of cadmium in the tissues and biological fluids as compared to injection of CdCl/sub 2/. A major percentage of cadmium was deposited in the kidney with urinary excretion after injection of rat cadmium-metallothionein to control rats. The biliary excretion of cadmium after cadmium-metallothionein injection was minimal. About 90% of cadmium in the kidney cortex and urine could be recovered as cadmium-thionein in sephadex gel filtration, 3 hr after cadmium-thionein injection.
- Research Organization:
- Univ. of Western Ontario, London
- OSTI ID:
- 7259706
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 2:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
UPTAKE
LIVER
RADIONUCLIDE KINETICS
ORGANIC NITROGEN COMPOUNDS
BIOSYNTHESIS
METABOLISM
ORGANIC SULFUR COMPOUNDS
THIONINE
BINDING ENERGY
CADMIUM CHLORIDES
KIDNEYS
RATS
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ENERGY
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SYNTHESIS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550501 - Metabolism- Tracer Techniques