Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC
Abstract
The macrocyclic antibiotic, vancomycin, was used as a chiral mobile phase additive for the thin layer chromatographic (TLC) resolution of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatized amino acids, racemic drugs and dansyl-amino acids. Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the organic modifier that produced the most effective separations with the shortest development times. It is highly likely that macrocyclic antibiotics will play a major role in future enantiomeric separations.
- Authors:
-
- Univ. of Missouri, Rolla, MO (United States). Dept. of Chemistry
- Publication Date:
- OSTI Identifier:
- 7254111
- DOE Contract Number:
- FG02-88ER13819
- Resource Type:
- Journal Article
- Journal Name:
- Journal of Liquid Chromatography; (United States)
- Additional Journal Information:
- Journal Volume: 17:8; Journal ID: ISSN 0148-3919
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ANTIBIOTICS; THIN-LAYER CHROMATOGRAPHY; ACCURACY; CHEMICAL COMPOSITION; PHASE STUDIES; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY; DRUGS; SEPARATION PROCESSES; 550600* - Medicine; 400102 - Chemical & Spectral Procedures
Citation Formats
Armstrong, D W, and Zhou, Y. Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC. United States: N. p., 1994.
Web. doi:10.1080/10826079408013451.
Armstrong, D W, & Zhou, Y. Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC. United States. https://doi.org/10.1080/10826079408013451
Armstrong, D W, and Zhou, Y. 1994.
"Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC". United States. https://doi.org/10.1080/10826079408013451.
@article{osti_7254111,
title = {Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC},
author = {Armstrong, D W and Zhou, Y},
abstractNote = {The macrocyclic antibiotic, vancomycin, was used as a chiral mobile phase additive for the thin layer chromatographic (TLC) resolution of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatized amino acids, racemic drugs and dansyl-amino acids. Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the organic modifier that produced the most effective separations with the shortest development times. It is highly likely that macrocyclic antibiotics will play a major role in future enantiomeric separations.},
doi = {10.1080/10826079408013451},
url = {https://www.osti.gov/biblio/7254111},
journal = {Journal of Liquid Chromatography; (United States)},
issn = {0148-3919},
number = ,
volume = 17:8,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}