Altered biodistribution of Ga-67 by intramuscular gold salts

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Clinical Nuclear Medicine; (USA)

DOI:https://doi.org/10.1097/00003072-198911000-00011· OSTI ID:7244570

Moult, R G; Bekerman, C ^[1]

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1. Chicago Osteopathic Medical Center, IL (USA)

The authors observed a deviation from the normal scintigraphic pattern of Ga-67 citrate biodistribution. An 8-year-old black girl with juvenile rheumatoid arthritis, who had been treated with intramuscular injections of gold salts, had a Ga-67 study as part of her workup. The study demonstrated no hepatic uptake, but showed elevated skeletal and renal activity. This characteristic biodistribution of Ga-67 may be due to inhibition of lysosomal enzymes by gold and/or to accumulation of gold in lysosomes. To study these possibilities, the authors reviewed the mechanisms of Ga-67 localization and gold metabolism. Alteration of the Ga-67 citrate scintigraphic pattern due to earlier treatment with gold salts has not been reported previously.

• OSTI ID: 7244570
• Journal Information: Clinical Nuclear Medicine; (USA), Vol. 14:11; ISSN 0363-9762
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 67
TISSUE DISTRIBUTION
GOLD
METABOLISM
RHEUMATIC DISEASES
DIAGNOSIS
CHILDREN
CITRATES
LYSOSOMES
SCINTISCANNING
AGE GROUPS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
CELL CONSTITUENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
TRANSITION ELEMENTS
550601* - Medicine- Unsealed Radionuclides in Diagnostics