Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children
- Wayne State Univ., Detroit, MI (USA)
Because prenatal exposure to polychlorinated biphenyls (PCBs) and related contaminants has been associated with reduced birth weight, neonatal behavioral anomalies, and poorer recognition memory in infants born to women who have consumed Lake Michigan sports fish, 236 children, previously evaluated for PCB-related deficits in infancy, were assessed at 4 years of age. Prenatal exposure (indicated by umbilical cord serum PCB level) predicted poorer short-term memory function on both verbal and quantitative tests in a dose-dependent fashion. These effects cannot be attributed to a broad range of potential confounding variables, the impact of which was evaluated statistically. Although much larger quantities of PCBs are transferred postnatally via lactation than prenatally across the placenta, exposure from nursing was unrelated to cognitive performance. The data demonstrate the continuation of a toxic impact received in utero and observed initially during infancy on a dimension of cognitive functioning fundamental to learning.
- OSTI ID:
- 7244293
- Journal Information:
- Journal of Pediatrics; (USA), Vol. 116:1; ISSN 0022-3476
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
TERATOGENESIS
FOOD CHAINS
CONTAMINATION
LAKE MICHIGAN
WATER POLLUTION
BLOOD
BODY BURDEN
FISHES
INFANTS
LACTATION
LEARNING
MILK
PREGNANCY
PRENATAL EXPOSURE
AGE GROUPS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL MATERIALS
BODY FLUIDS
CHILDREN
FOOD
GREAT LAKES
HALOGENATED AROMATIC HYDROCARBONS
LAKES
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
SURFACE WATERS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology