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Title: Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. [X radiation, mice]

Abstract

Spleen cells from newborn syngeneic and allogeneic mice that lack fully differentiated T lymphocytes can be used as a hematopoietic source to reconstitute both hematopoietic and lymphoid systems of lethally irradiated mice without producing a GVHR. Fetal liver cells from syngeneic and allogeneic mice that lack postthymic T lymphocytes can also be used for hematopoietic and immunologic reconstitution of lethally irradiated mice without producing GVHR. Immunologic deficiency is observed in some experiments in mice given supralethal irradiation (1000 R) and fetal liver as reconstituting hematopoietic tissue. The findings suggest that T cells, at an early stage of differentiation, are more susceptible to tolerance induction than are T lymphocytes at later stages of differentiation and do not, in general, produce GVHR. It is postulated that hematopoietic cells, free of postthymic lymphoid cells, can be used for hematopoietic or immunologic reconstitution and celular engineering without producing GVHD.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Minnesota, Minneapolis
OSTI Identifier:
7227704
Resource Type:
Journal Article
Journal Name:
Transplant. Proc.; (United States)
Additional Journal Information:
Journal Volume: 8:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNE REACTIONS; BIOLOGICAL RADIATION EFFECTS; LIVER; TRANSPLANTS; SPLEEN CELLS; ANIMAL CELLS; FETUSES; GRAFT-HOST REACTION; HEMATOPOIETIC SYSTEM; LYMPHOCYTES; MICE; NEONATES; SURVIVAL TIME; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; GLANDS; IONIZING RADIATIONS; LEUKOCYTES; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Yunis, E.J., Fernandes, G., Smith, J., and Good, R.A. Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. [X radiation, mice]. United States: N. p., 1976. Web.
Yunis, E.J., Fernandes, G., Smith, J., & Good, R.A. Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. [X radiation, mice]. United States.
Yunis, E.J., Fernandes, G., Smith, J., and Good, R.A. Wed . "Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. [X radiation, mice]". United States.
@article{osti_7227704,
title = {Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. [X radiation, mice]},
author = {Yunis, E.J. and Fernandes, G. and Smith, J. and Good, R.A.},
abstractNote = {Spleen cells from newborn syngeneic and allogeneic mice that lack fully differentiated T lymphocytes can be used as a hematopoietic source to reconstitute both hematopoietic and lymphoid systems of lethally irradiated mice without producing a GVHR. Fetal liver cells from syngeneic and allogeneic mice that lack postthymic T lymphocytes can also be used for hematopoietic and immunologic reconstitution of lethally irradiated mice without producing GVHR. Immunologic deficiency is observed in some experiments in mice given supralethal irradiation (1000 R) and fetal liver as reconstituting hematopoietic tissue. The findings suggest that T cells, at an early stage of differentiation, are more susceptible to tolerance induction than are T lymphocytes at later stages of differentiation and do not, in general, produce GVHR. It is postulated that hematopoietic cells, free of postthymic lymphoid cells, can be used for hematopoietic or immunologic reconstitution and celular engineering without producing GVHD.},
doi = {},
journal = {Transplant. Proc.; (United States)},
number = ,
volume = 8:4,
place = {United States},
year = {1976},
month = {12}
}