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Title: Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients

Abstract

HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous anterior uveitis and have confirmed this relation. In addition, using 90m technetium stannous pyrophosphate we have been able to demonstrate abnormal bone scan in 19 of 30 patients studied. Such abnormalities are limited to the sacroiliac joints but are otherwise the same as those seen in overt ankylosing spondylitis. Seven of the 19 patients did not have HLA-B27. These factors suggest that acute anterior uveitis may often represent a manifestation of a spondylitic diathesis even in the complete absence of any suggestive symptomatic or radiologic change and, in some cases, even through the antigenic marker HLA-B27 may be absent.

Authors:
; ; ;
Publication Date:
OSTI Identifier:
7226302
Resource Type:
Journal Article
Journal Name:
Ann. Intern. Med.; (United States)
Additional Journal Information:
Journal Volume: 85:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE JOINTS; SCINTISCANNING; SKELETAL DISEASES; DIAGNOSIS; TECHNETIUM 99; ANTIGENS; IMMUNOLOGY; ISOMERIC NUCLEI; PATIENTS; PYROPHOSPHATES; SPONDYLITIS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SKELETON; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Russell, A S, Lentle, B C, Percy, J S, and Jackson, F I. Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients. United States: N. p., 1976. Web. doi:10.7326/0003-4819-85-5-606.
Russell, A S, Lentle, B C, Percy, J S, & Jackson, F I. Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients. United States. https://doi.org/10.7326/0003-4819-85-5-606
Russell, A S, Lentle, B C, Percy, J S, and Jackson, F I. 1976. "Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients". United States. https://doi.org/10.7326/0003-4819-85-5-606.
@article{osti_7226302,
title = {Scintigraphy of sacroliac joints in acute anterior uveitis. A study of thirty patients},
author = {Russell, A S and Lentle, B C and Percy, J S and Jackson, F I},
abstractNote = {HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous anterior uveitis and have confirmed this relation. In addition, using 90m technetium stannous pyrophosphate we have been able to demonstrate abnormal bone scan in 19 of 30 patients studied. Such abnormalities are limited to the sacroiliac joints but are otherwise the same as those seen in overt ankylosing spondylitis. Seven of the 19 patients did not have HLA-B27. These factors suggest that acute anterior uveitis may often represent a manifestation of a spondylitic diathesis even in the complete absence of any suggestive symptomatic or radiologic change and, in some cases, even through the antigenic marker HLA-B27 may be absent.},
doi = {10.7326/0003-4819-85-5-606},
url = {https://www.osti.gov/biblio/7226302}, journal = {Ann. Intern. Med.; (United States)},
number = ,
volume = 85:5,
place = {United States},
year = {Mon Nov 01 00:00:00 EST 1976},
month = {Mon Nov 01 00:00:00 EST 1976}
}