Initial part of the survival curve. Implications for low-dose, low-dose-rate radiation responses

Conference · Fri Jul 01 00:00:00 EDT 1977 · Radiat. Res.; (United States)

OSTI ID:7221788

Elkind, M M

Aspects of radiation exposure that relate to epidemiological questions generally focus upon late effects due to low doses delivered at low dose rates. Among the questions of major concern, oncogenesis, mutagenesis, and teratogenesis are of primary interest, but in each case cell killing must also be considered. At the cellular level, few data exist relative to the foregoing except for cell killing but, even in the latter instance, technical difficulties impose limitations on the generalizations that may be inferred. Using cell survival as a model, several formal dose-effect relationships are discussed, particularly in reference to the low-dose region of the survival curve, and a summary of available survival data is presented. Of particular interest is the biophysics underlying so-called ''single-hit'' inactivation. The theory of exponential (or linear) dose-effect dependencies is presented, from which the conclusion is reached that in single-hit killing, the level of damage expressed (i.e., the inactivation constant) may be modified by postirradiation cellular processes reflecting damage repair or enhanced damage expression.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 7221788
• Journal Information: Radiat. Res.; (United States), Vol. 71:1; Conference: Joint annual scientific meeting of the Radiation Research Society and the Health Physics Society, San Francisco, CA, USA, 29 Jun 1976
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
SURVIVAL CURVES
CELL KILLING
RADIOINDUCTION
LOW DOSE IRRADIATION
MATHEMATICAL MODELS
PLANT CELLS
TUMOR CELLS
DOSE-RESPONSE RELATIONSHIPS
IRRADIATION
560121* - Radiation Effects on Cells- External Source- (-1987)