Polychlorinated biphenyl (PCB) congener effects on the longevity of the housefly
- Univ. of Illinois, Urbana (United States)
The microsomal monooxygenase system in the housefly is well-characterized, active, inducible and inhibited by the same types of compounds as in vertebrate systems. Flies metabolize PCBs to polar products and retain congeners from a commercial mixture in proportions consistent with PCB biotransformation and elimination in vertebrates. Although TCDD has been shown to have a high affinity for, and be an effective agonist of the juvenile hormone receptor in insects, toxic manifestations in adult insects may differ from those in certain highly sensitive vertebrate species. This study was undertaken to determine if the housefly bioassay could effectively compare the net adverse biological activity of a group of PCB congeners independent of Ah receptor effects.
- OSTI ID:
- 7206302
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 48:1; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL EFFECTS
ENZYME ACTIVITY
FLIES
MICROSOMES
MIXED-FUNCTION OXIDASES
RECEPTORS
ANIMALS
AROMATICS
ARTHROPODS
CELL CONSTITUENTS
DIPTERA
ENZYMES
HALOGENATED AROMATIC HYDROCARBONS
INSECTS
INVERTEBRATES
MEMBRANE PROTEINS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PROTEINS
RIBOSOMES
560300* - Chemicals Metabolism & Toxicology