Effect of intrauterine PCB (polychlorinated biphenyls) exposure on visual recognition memory
Adverse neonatal outcomes have been associated with intrauterine exposure to polychlorinated biphenyls (PCBs). In a follow-up study of exposed and nonexposed infants, 123 infants tested at birth were administered Fagan's test of visual recognition memory at 7 months. Two measures of prenatal PCB exposure, cord serum PCB level and maternal report of contaminated fish consumption, predicted less preference for a novel stimulus. Preference for novelty decreased in a dose-dependent fashion with increasing levels of prenatal PCB exposure. Postnatal exposure from nursing was not related to visual recognition memory. The relation between prenatal exposure and visual recognition was not mediated by the neonatal deficits, suggesting that intrauterine PCB exposure may have a delayed effect on central nervous system functioning.
- Research Organization:
- Wayne State Univ., Detroit, MI (USA)
- OSTI ID:
- 7194236
- Report Number(s):
- PB-90-146259/XAB
- Resource Relation:
- Other Information: Pub. in Child Development 56, 853-860(1985)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CENTRAL NERVOUS SYSTEM
SENSITIVITY
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
CONTAMINATION
DOSE-RESPONSE RELATIONSHIPS
FISHES
FOOD CHAINS
INFANTS
PRENATAL EXPOSURE
AGE GROUPS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
CHILDREN
HALOGENATED AROMATIC HYDROCARBONS
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology