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Title: Plasma membrane reorganization induced by chemical transformation in cultura

Technical Report ·
OSTI ID:7192531

Induction of increased rigidity in the plasma membrane paralleling properties associated with a transformed state was suggested by two experiments. Fluorescence recovery after photobleaching (FRAP) indicated the induction of an environment in the plasma membrane where the synthetic fluorescent phospholipid collarein was immobile on the FRAP timescale. The other technique revealed the binding of epidermal growth factor (EGF) to a cryptic class of receptors which become accessible upon chemical transformation. These two lines of evidence are consistent with a reorganization of the plasma membrane induced by tumor promoters. 110 references, 38 figures, 4 tables.

Research Organization:
Lawrence Berkeley Lab., CA (USA)
DOE Contract Number:
AC03-76SF00098
OSTI ID:
7192531
Report Number(s):
LBL-17712; ON: DE84012311
Resource Relation:
Other Information: Portions are illegible in microfiche products. Thesis
Country of Publication:
United States
Language:
English