Effect of dietary iron source and iron status on iron bioavailability tests in the rat
Abstract
Weanling male rats were made anemic in 7 days by feeding a low iron diet and bleeding. Healthy rats were fed the low iron diet supplemented with ferrous sulfate (29 ppm Fe). Each group was subdivided and fed for 10 days on test diets containing about 29 ppm iron that were formulated with meat:spinach mixtures or meat:soy mixtures to provided 100:0, 75:25, 50:50, 25:75, or 0:100% of the dietary iron from these sources or from a ferrous sulfate diet. After 3 days on the diets all rats were dosed orally with 2 or 5 micro curries of /sup 59/Fe after a 18 hour fast and refeeding for 1.5 hours. Iron status influenced liver iron, carcass iron, liver radio activity and percent of radioactive dose retained. Diet influenced fecal iron and apparent absorption of iron. In iron bioavailability studies assessment methodology and iron status of the test subject greatly influences the estimates of the value of dietary sources of iron.
- Authors:
- Publication Date:
- Research Org.:
- Utah State Univ., Logan
- OSTI Identifier:
- 7188900
- Report Number(s):
- CONF-8604222-
Journal ID: CODEN: FEPRA
- Resource Type:
- Conference
- Journal Name:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
- Additional Journal Information:
- Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; IRON; BIOLOGICAL AVAILABILITY; METABOLISM; DIET; IRON 59; RATS; TRACER TECHNIQUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METALS; NUCLEI; RADIOISOTOPES; RODENTS; TRANSITION ELEMENTS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
Citation Formats
Zhang, D, Hendricks, D G, and Mahoney, A W. Effect of dietary iron source and iron status on iron bioavailability tests in the rat. United States: N. p., 1986.
Web.
Zhang, D, Hendricks, D G, & Mahoney, A W. Effect of dietary iron source and iron status on iron bioavailability tests in the rat. United States.
Zhang, D, Hendricks, D G, and Mahoney, A W. 1986.
"Effect of dietary iron source and iron status on iron bioavailability tests in the rat". United States.
@article{osti_7188900,
title = {Effect of dietary iron source and iron status on iron bioavailability tests in the rat},
author = {Zhang, D and Hendricks, D G and Mahoney, A W},
abstractNote = {Weanling male rats were made anemic in 7 days by feeding a low iron diet and bleeding. Healthy rats were fed the low iron diet supplemented with ferrous sulfate (29 ppm Fe). Each group was subdivided and fed for 10 days on test diets containing about 29 ppm iron that were formulated with meat:spinach mixtures or meat:soy mixtures to provided 100:0, 75:25, 50:50, 25:75, or 0:100% of the dietary iron from these sources or from a ferrous sulfate diet. After 3 days on the diets all rats were dosed orally with 2 or 5 micro curries of /sup 59/Fe after a 18 hour fast and refeeding for 1.5 hours. Iron status influenced liver iron, carcass iron, liver radio activity and percent of radioactive dose retained. Diet influenced fecal iron and apparent absorption of iron. In iron bioavailability studies assessment methodology and iron status of the test subject greatly influences the estimates of the value of dietary sources of iron.},
doi = {},
url = {https://www.osti.gov/biblio/7188900},
journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:4,
place = {United States},
year = {Wed Mar 05 00:00:00 EST 1986},
month = {Wed Mar 05 00:00:00 EST 1986}
}