Radiopharmaceuticals for imaging the heart

Patent · Tue Jun 28 00:00:00 EDT 1994

OSTI ID:7172837

Green, M A; Tsang, B W

Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

• DOE Contract Number: FG02-89ER60868
• Assignee: Purdue Research Foundation, West Lafayette, IN (United States)
• Patent Number(s): US 5324502; A
• Application Number: CNN: R01-CA46909; PPN: US 7-861778
• OSTI ID: 7172837
• Resource Relation: Patent File Date: 2 Apr 1992
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 68
UPTAKE
HEART
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
SYNTHESIS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics