New [sup 99m]Tc, [sup 186]Re, and [sup 109]Pd complexes of SN and PN ligand systems
The development of new site specific radioisotope tracers which would permit quantitative in vitro and in vivo studies of physiological and biochemical processes continues to be an essential aspect in the design of new radiopharmaceuticals for diagnostic and therapeutic applications. In carrying out this objective, a new class of ligand frameworks based on the conventional amine thiol ligands and the unconventional PN ligand systems were designed for use in labeling proteins and monoclonal antibodies with both gamma and beta emitting isotopes for potential use as radioimmunodiagnostic and radioimmunotherapeutic agents respectively. Systematic synthetic investigation involved the development of new N[sub 3]S[sub 2] and main group PN ligands and their chemical tuning to achieve optimal in vitro and in vivo stability characteristics of the resulting metal chelates. The fundamental coordination chemistry of these ligands with different transition metals (e.g., Pd, Re) was developed to gain insight into their reactivity with both early and late transition metal radionuclides. Detailed characterization of these ligands and their metal complexes were undertaken via various analytical, spectroscopic and extensive X-ray crystallographic techniques. The ligands were labeled with [sup 99m]Tc, [sup 186]Re and [sup 109]Pd and their complexation yields determined. The radiochelates were analyzed for their radiochemical purity and in vitro stability and characterized by various radiochemical techniques. The new bifunctional chelating agents were used to label human IgG with [sup 99m]Tc. The conjugation yields and the in vitro stabilities of these radiolabeled proteins were examined. The results of these studies demonstrate the potential utility of using a wide spectrum of S-N and P-N based ligands to produce a new genre of complexes for the development of future radiopharmaceuticals and bioconjugates.
- Research Organization:
- Missouri Univ., Columbia, MO (United States)
- OSTI ID:
- 7165654
- Resource Relation:
- Other Information: Thesis (Ph.D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PALLADIUM COMPLEXES
CHEMICAL PREPARATION
RADIOCHEMISTRY
RHENIUM COMPLEXES
TECHNETIUM COMPLEXES
TRACER TECHNIQUES
LIGANDS
LABELLING
PALLADIUM 109
RADIOPHARMACEUTICALS
RHENIUM 186
STRUCTURAL CHEMICAL ANALYSIS
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMISTRY
COMPLEXES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PALLADIUM ISOTOPES
RADIOISOTOPES
RHENIUM ISOTOPES
SYNTHESIS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOI
YEARS LIVING RADIOISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials