Investigation into the combined effects of X-irradiation and 3MHz ultrasound-induced hyperthermia on pig skin
The thermal enhancement of radiation-induced damage in pig skin has been investigated. Heating at 43 degrees C for 60 min was produced by a scanned 3MHz ultrasound transducer, immediately after single doses of X rays. The ED50 values for the dermal reactions of dusky/mauve erythema and necrosis after irradiation alone were 18.6 +/- 0.5 Gy and 20.5 +/- 0.4 Gy, respectively. The reduction in the ED50 values to 15.3 +/- 0.4 Gy and 17.7 +/- 0.5 Gy after irradiation plus heating was significant and suggested a thermal enhancement ratio (TER) of between 1.15 and 1.22. These TER values were within the range obtained in both pig and rat skin using other dry heating methods. This would suggest that the non-thermal effects of ultrasound do not influence the thermal enhancement of x-irradiation damage.
- Research Organization:
- Institute of Cancer Research, Sutton, Surrey (England)
- OSTI ID:
- 7151942
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 14:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEAT
RADIOSENSITIVITY EFFECTS
HYPERTHERMIA
RADIOINDUCTION
SKIN
BIOLOGICAL RADIATION EFFECTS
RADIATION INJURIES
SWINE
SYNERGISM
ULTRASONOGRAPHY
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ENERGY
INJURIES
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals