Electrophoresis-mass spectrometry probe

Patent · Tue Nov 10 00:00:00 EST 1987

OSTI ID:7148094

Andresen, B D; Fought, E R

The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface. 8 figs.

• DOE Contract Number: W-7405-ENG-48
• Assignee: Sepragen Corp., San Leandro, CA (United States)
• Patent Number(s): US 4705616; A
• Application Number: PPN: US 6-906847
• OSTI ID: 7148094
• Resource Relation: Patent File Date: 15 Sep 1986
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
MASS SPECTROMETERS
PROBES
MIXTURES
ELECTROPHORESIS
MASS SPECTROSCOPY
DESIGN
EQUIPMENT INTERFACES
REAL TIME SYSTEMS
SEPARATION PROCESSES
DISPERSIONS
MEASURING INSTRUMENTS
SPECTROMETERS
SPECTROSCOPY
400102* - Chemical & Spectral Procedures
400105 - Separation Procedures