Chemical protection against the long-term effects of a single whole-body exposure of mice to ionizing radiation. I. Life shortening. [X radiation]
A systematic study has been made of the advantages gained by treatment with combined radiochemical protectors for long-term survival of mice exposed to a single dose of ionizing radiation. Our results demonstrate that mixtures of radioprotectors increase the degree of protection compared with that obtained with each substance given separately. The dose-effect curves for the long-term survival obtained for irradiated untreated mice and for mice treated with a mixture of radioprotectors are not parallel. Thus the dose-reduction factor (DRF) varies with the X-ray dose administered. The optimum DRF obtained for long-term survival of BALB/c/sup +/ mice (2.5) was very close to that obtained against acute effects of ionizing radiation (2.8).
- Research Organization:
- CEN/SCK, Mol, Belgium
- OSTI ID:
- 7142659
- Journal Information:
- Radiat. Res.; (United States), Vol. 71:1
- Country of Publication:
- United States
- Language:
- English
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LONG-TERM EFFECTS OF A SINGLE WHOLE-BODY EXPOSURE OF MICE TO IONIZING RADIATIONS. I. LIFE-SHORTENING
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Related Subjects
RADIOPROTECTIVE SUBSTANCES
BIOLOGICAL EFFECTS
SURVIVAL CURVES
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MICE
X RADIATION
ANIMALS
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
RADIATION EFFECTS
RADIATIONS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals