Autoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig hearts

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Circulation; (USA)

DOI:https://doi.org/10.1161/01.CIR.81.3.741· OSTI ID:7137881

Coupe, M O; Mak, J C; Yacoub, M; Oldershaw, P J; Barnes, P J ^[1]

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1. Brompton Hospital, London (England)

Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is a potent coronary vasodilator. Although CGRP is found in high concentrations around coronary arteries, its precise function in the control of coronary vasomotor tone remains unclear. We studied the distribution of specific receptors for CGRP in guinea pig and human hearts and found that the highest concentration of specific receptors for CGRP was in the major coronary arteries, which is consistent with the hypothesis that CGRP is implicated in control of coronary vasomotor tone. Areas of coronary artery with atheroma contained significantly decreased (158 +/- 35 grains/1,000 microns 2 tissue, n = 3) binding sites compared with binding sites in normal arteries (266 +/- 10 grains/1,000 microns 2 tissue, n = 11; p less than 0.001, t test). The decrease in receptors for CGRP around atheroma may predispose these vessels to coronary spasm.

• OSTI ID: 7137881
• Journal Information: Circulation; (USA), Vol. 81:3; ISSN 0009-7322
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ARTERIOSCLEROSIS
PATHOGENESIS
PEPTIDES
RECEPTORS
TISSUE DISTRIBUTION
AUTORADIOGRAPHY
CALCITONIN
CORONARIES
GUINEA PIGS
IODINE ISOTOPES
MAN
MYOCARDIUM
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DISTRIBUTION
HEART
HORMONES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
MUSCLES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
POLYPEPTIDES
PRIMATES
PROTEINS
RODENTS
VASCULAR DISEASES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques