Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction

Kido, T; Nogawa, K; Ishizaki, M; Honda, R; Tsuritani, I; Yamada, Y; Nakagawa, H; Nishi, M

doi:10.1080/00039896.1990.9935922

Title: Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction

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Abstract

Twenty-one subjects who had cadmium (Cd)-induced renal dysfunction and who lived in a Cd-polluted area in Japan were investigated to determine changes in their renal function. Since 1974, serum creatinine and arterial blood pH were measured annually during the autumn months for 9-14 y. Mean serum creatinine was significantly increased during this period, i.e., from 1.19 +/- 1.28 mg/100 ml to 1.68 +/- 1.56 mg/100 ml. Even after cadmium exposure ceased, significant deterioration of glomerular filtration was found. Eleven subjects showed a greater than 20% serum creatinine increase during this period. The most severe case had a serum creatinine value of 4.4 mg/100 ml at the most recent examination and experienced generalized edema, which suggests a clinical diagnosis of renal failure. The mean arterial blood pH values decreased significantly in all subjects, i.e., from 7.400 +/- 0.023 to 7.361 +/- 0.034. The 11 subjects cited above also showed a significant decrease and progression of tubular dysfunction after Cd exposure ceased. Our findings suggest that Cd-induced renal tubular dysfunction and decreased glomerular filtration are aggravated even after cessation of environmental Cd exposure, and in some cases this renal dysfunction may progress to renal failure.

Authors:

Kido, T; Nogawa, K; Ishizaki, M; Honda, R; Tsuritani, I; Yamada, Y; Nakagawa, H; Nishi, M ^[1]

Kanazawa Medical Univ., Ishikawa (Japan)

Publication Date:: Mon Jan 01 00:00:00 EST 1990

OSTI Identifier:: 7136077

Resource Type:: Journal Article

Journal Name:: Archives of Environmental Health; (USA)

Additional Journal Information:: Journal Volume: 45:1; Journal ID: ISSN 0003-9896

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; TOXICITY; FOOD CHAINS; CONTAMINATION; UROGENITAL SYSTEM DISEASES; EPIDEMIOLOGY; BLOOD; CREATININE; ENVIRONMENTAL EXPOSURE; JAPAN; MAN; PH VALUE; TUBULES; ANIMALS; ASIA; AZOLES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; DISEASES; ELEMENTS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; IMINES; KIDNEYS; MAMMALS; MATERIALS; METALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats


                    Kido, T, Nogawa, K, Ishizaki, M, Honda, R, Tsuritani, I, Yamada, Y, Nakagawa, H, and Nishi, M. Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction.  United States: N. p., 1990. 
        Web.  doi:10.1080/00039896.1990.9935922.

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                    Kido, T, Nogawa, K, Ishizaki, M, Honda, R, Tsuritani, I, Yamada, Y, Nakagawa, H, & Nishi, M. Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction.  United States.  https://doi.org/10.1080/00039896.1990.9935922

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                    Kido, T, Nogawa, K, Ishizaki, M, Honda, R, Tsuritani, I, Yamada, Y, Nakagawa, H, and Nishi, M. 1990.  
        "Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction".  United States.  https://doi.org/10.1080/00039896.1990.9935922.

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@article{osti_7136077,

  title        = {Long-term observation of serum creatinine and arterial blood pH in persons with cadmium-induced renal dysfunction},

  author       = {Kido, T and Nogawa, K and Ishizaki, M and Honda, R and Tsuritani, I and Yamada, Y and Nakagawa, H and Nishi, M},

  abstractNote = {Twenty-one subjects who had cadmium (Cd)-induced renal dysfunction and who lived in a Cd-polluted area in Japan were investigated to determine changes in their renal function. Since 1974, serum creatinine and arterial blood pH were measured annually during the autumn months for 9-14 y. Mean serum creatinine was significantly increased during this period, i.e., from 1.19 +/- 1.28 mg/100 ml to 1.68 +/- 1.56 mg/100 ml. Even after cadmium exposure ceased, significant deterioration of glomerular filtration was found. Eleven subjects showed a greater than 20% serum creatinine increase during this period. The most severe case had a serum creatinine value of 4.4 mg/100 ml at the most recent examination and experienced generalized edema, which suggests a clinical diagnosis of renal failure. The mean arterial blood pH values decreased significantly in all subjects, i.e., from 7.400 +/- 0.023 to 7.361 +/- 0.034. The 11 subjects cited above also showed a significant decrease and progression of tubular dysfunction after Cd exposure ceased. Our findings suggest that Cd-induced renal tubular dysfunction and decreased glomerular filtration are aggravated even after cessation of environmental Cd exposure, and in some cases this renal dysfunction may progress to renal failure.},

  doi          = {10.1080/00039896.1990.9935922},

  url          = {https://www.osti.gov/biblio/7136077},
  journal      = {Archives of Environmental Health; (USA)},

  issn         = {0003-9896},

  number       = ,

  volume       = 45:1,

  place        = {United States},

  year         = {Mon Jan 01 00:00:00 EST 1990},

  month        = {Mon Jan 01 00:00:00 EST 1990}

}

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