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Title: Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience

Abstract

The risk of leukemia associated with the first course of cancer treatment was evaluated in over 440,000 patients diagnosed during 1973-80 (average follow-up . 1.91 yr) from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Although the reporting of the first course of therapy probably was incomplete, 34 acute nonlymphocytic leukemias (ANLL) developed compared with 7.6 expected among 70,674 patients known to receive initial chemotherapy (relative risk (RR) . 4.5, 95% confidence interval (Cl) . 3.1-6.3). Significant ANLL excesses were observed following chemotherapy for breast cancer (RR . 8.1), ovarian cancer (RR . 22.2), and multiple myeloma (RR . 9.5). Patients initially treated with radiation (with no record of chemotherapy) also had a significantly increased ANLL risk; 45 leukemias occurred versus 17.9 expected (RR . 2.5, 95% Cl . 1.8-3.4). In this group, excess ANLL were found following irradiation for uterine corpus cancer (RR . 4.0). Kidney and renal pelvis cancer patients had a twofold leukemia risk (all types) that was unrelated to treatment (RR . 2.2).

Authors:
; ; ;
Publication Date:
Research Org.:
Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, MD
OSTI Identifier:
7133467
Resource Type:
Journal Article
Journal Name:
J. Natl. Cancer Inst.; (United States)
Additional Journal Information:
Journal Volume: 72:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEUKEMIA; RADIOINDUCTION; RADIOTHERAPY; SIDE EFFECTS; CHEMOTHERAPY; PATIENTS; RISK ASSESSMENT; DISEASES; HEMIC DISEASES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Curtis, R.E., Hankey, B.F., Myers, M.H., and Young, J.L. Jr.. Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience. United States: N. p., 1984. Web.
Curtis, R.E., Hankey, B.F., Myers, M.H., & Young, J.L. Jr.. Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience. United States.
Curtis, R.E., Hankey, B.F., Myers, M.H., and Young, J.L. Jr.. Thu . "Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience". United States.
@article{osti_7133467,
title = {Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience},
author = {Curtis, R.E. and Hankey, B.F. and Myers, M.H. and Young, J.L. Jr.},
abstractNote = {The risk of leukemia associated with the first course of cancer treatment was evaluated in over 440,000 patients diagnosed during 1973-80 (average follow-up . 1.91 yr) from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Although the reporting of the first course of therapy probably was incomplete, 34 acute nonlymphocytic leukemias (ANLL) developed compared with 7.6 expected among 70,674 patients known to receive initial chemotherapy (relative risk (RR) . 4.5, 95% confidence interval (Cl) . 3.1-6.3). Significant ANLL excesses were observed following chemotherapy for breast cancer (RR . 8.1), ovarian cancer (RR . 22.2), and multiple myeloma (RR . 9.5). Patients initially treated with radiation (with no record of chemotherapy) also had a significantly increased ANLL risk; 45 leukemias occurred versus 17.9 expected (RR . 2.5, 95% Cl . 1.8-3.4). In this group, excess ANLL were found following irradiation for uterine corpus cancer (RR . 4.0). Kidney and renal pelvis cancer patients had a twofold leukemia risk (all types) that was unrelated to treatment (RR . 2.2).},
doi = {},
journal = {J. Natl. Cancer Inst.; (United States)},
number = ,
volume = 72:3,
place = {United States},
year = {1984},
month = {3}
}