Collision processes in triple quadrupole mass spectrometry: characteristics and applications
Characteristics of collision processes in the quadrupole collision chamber of a triple quadrupole mass spectrometer are explored. Results are used to aid in the analytical application of collisionally activated dissociation (CAD) and collisionally activated reactions (CAR) that occur through the ion-molecule interactions in the quadrupole collision chamber. Ions formed in the ion source are selected by their mass-to-charge ratio in the first quadrupole to pass into the pressurized RF-only quadrupole collision chamber. Interaction of the low energy (<200 eV) selected ion with the target gas present in the collision chamber leads to an increase of the ion's internal energy and its subsequent dissociation or to an ion-molecule reaction with the target gas. The ionic collision products are mass analyzed by the third quadrupole and detected. An RF-only quadrupole exhibits no discrimination of mass-to-charge values and strongly focuses all scattered ions. The spectra produced via CAD or CAR in a triple quadrupole mass spectrometer are easy to interpret as unit mass resolution is preserved for both selection of reactant ions and analysis of ionic products. Application of CAD to the identification of compounds present in the acid fraction of the priority pollutants is presented. Application of CAR for differentiating among different hydroxy- and halogen-containing aromatic positional isomers is described.
- Research Organization:
- Michigan State Univ., East Lansing (USA)
- OSTI ID:
- 7128463
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
47 OTHER INSTRUMENTATION
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHEMICAL ANALYSIS
ION-MOLECULE COLLISIONS
MASS SPECTROMETERS
POLLUTANTS
FOCUSING
QUADRUPOLAR CONFIGURATIONS
QUADRUPOLES
REACTION KINETICS
CLOSED CONFIGURATIONS
COLLISIONS
ION COLLISIONS
KINETICS
MAGNETIC FIELD CONFIGURATIONS
MEASURING INSTRUMENTS
MOLECULE COLLISIONS
MULTIPOLAR CONFIGURATIONS
MULTIPOLES
SPECTROMETERS
640304* - Atomic
Molecular & Chemical Physics- Collision Phenomena
440300 - Miscellaneous Instruments- (-1989)
400102 - Chemical & Spectral Procedures