Induction of tolerance to cardiac allografts by irradiation and bone marrow transplantation

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Surg. Forum; (United States)

OSTI ID:7120479

Boyd, A D; Spencer, F C; Hirose, H; Engelman, R M; Cannon, F D; Ferrebee, J W; Rapaport, F T

It is generally agreed that most, if not all, technical problems of cardiac transplantation in experimental animals and in human subjects have been mastered. Successful application of this technique to the treatment of end-stage cardiac disease continues to be hampered, however, by the host's reaction to a cardiac allograft as foreign tissue, and his attempt to destroy such tissue by immunological reactions normally implicated in defense mechanisms against infectious microorganisms. Earlier studies in this laboratory have demonstrated that DL-A compatibility can exert a potent influence on the survival of orthotopic cardiac allografts in the unmodified canine host. The present report demonstrates that supralethal total body irradiation and bone marrow transplantation from a genotypically DL-A identical donor can induce in canine recipients an immunologically specific state of unresponsiveness to an orthotopic heart transplant obtained from the marrow donor.

• Research Organization: New York Univ.
• OSTI ID: 7120479
• Journal Information: Surg. Forum; (United States), Vol. 26
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
BONE MARROW CELLS
COBALT 60
DOGS
GAMMA RADIATION
HEART
SUPRALETHAL IRRADIATION
TRANSPLANTS
WHOLE-BODY IRRADIATION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals