Xeroderma pigmentosum: biochemical and genetic characteristics

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Annu. Rev. Genet.; (United States)

DOI:https://doi.org/10.1146/annurev.ge.09.120175.000315· OSTI ID:7110279

Cleaver, J E ^[1]; Bootsma, D

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1. Univ. of California, San Francisco

Biochemical and genetic studies on xeroderma pigmentosum are reviewed under the following headings: clinical features of xeroderma pigmentosum; karyotype; cell killing and host cell reactivation after irradiation or exposure to chemical carcinogens; SV40 transformation of xeroderma pigmentosum cells; biochemical defects in the common and de Sanctis-Cacchione forms of xeroderma pigmentosum; cell hybridization and complementation groups; biochemical defects in the xeroderma pigmentosum variant and the role of caffeine in DNA repair; DNA repair in xeroderma pigmentosum heterozygotes; response of xeroderma pigmentosum cells to various mutagens and chemical carcinogens; other high and low repair diseases; and possible significance of DNA repair in theories of aging and carcinogenesis. (HLW)

• OSTI ID: 7110279
• Journal Information: Annu. Rev. Genet.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
BIOLOGICAL EFFECTS
CARCINOGENS
DNA
BIOLOGICAL REPAIR
MUTAGENS
SKIN DISEASES
BIOCHEMISTRY
GENETICS
CELL KILLING
HYBRIDIZATION
KARYOTYPE
REVIEWS
BIOLOGICAL RECOVERY
BIOLOGY
CHEMISTRY
DISEASES
DOCUMENT TYPES
DRUGS
HETEROCYCLIC COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RECOVERY
REPAIR
XANTHINES
550400* - Genetics
550200 - Biochemistry