Graft-versus-host reaction-like phenomenon induced by BCG in mice lethally irradiated and transferred with syngeneic bone marrow cells. [X Radiation, Bacillus Calmette-Guerin]
Heat-killed BCG in paraffin exerted a lethal effect on C57BL/6 mice irradiated lethally and transferred with syngeneic bone marrow cells. Such an effect was not detectable when mice were subjected to adult thymectomy and used as the hosts. Lymphoid cells from such nonthymectomized mice exhibited cytotoxicity to syngeneic tumor cells but not to allogeneic tumor cells in an in vivo cytotoxicity test and induced splenomegaly in sublethally irradiated syngeneic recipients after systemic transfer. The cytotoxicity of such lymphoid cells was abolished by a treatment with anti-theta serum and complement. In the bone marrow of mice irradiated and transferred with bone marrow cells, the number of nucleated cells, the ratio of mycloid to erythroid cell series, and the percentage of lymphocytes were increased by BCG injection. These results suggest the possibility that self-tolerance may be broken by BCG injection. These results suggest the possibility that self-tolerance may be broken by BCG stimulation in the process of reconstitution of lymphoid cells in the irradiated mice.
- Research Organization:
- Kyushu Univ., Fukuoka, Japan
- OSTI ID:
- 7110131
- Journal Information:
- Cell. Immunol.; (United States), Vol. 29:2
- Country of Publication:
- United States
- Language:
- English
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BACILLUS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
TRANSPLANTS
GRAFT-HOST REACTION
IMMUNE REACTIONS
BLOOD SERUM
HEAT TREATMENTS
LETHAL IRRADIATION
LYMPHOCYTES
MICE
THYMECTOMY
TOXICITY
TUMOR CELLS
X RADIATION
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MAMMALS
MEDICINE
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SURGERY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals