X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-iodouridylyl(3'-5')adenosine (drug-nucleic acid interactions/intercalation/double helix unwinding)
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The drug ethidium bromide has been cocrystallized with the dinucleoside monophosphate 5-iodouridylyl (3'-5')adenosine. The three-dimensional structure to atomic resolution by x-ray crystallography was solved. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.
- Research Organization:
- Univ. of Rochester, NY (United States)
- OSTI ID:
- 7107105
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 72:2
- Country of Publication:
- United States
- Language:
- English
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Mon Jan 01 00:00:00 EST 1979
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OSTI ID:7107105