The effect of exposure to 1,2,4,5-tetrachlorobenzene and the relationship between toxicant and oxygen uptake in rainbow trout (Oncorhynchus mykiss) during exercise

Journal Article · Tue Nov 01 00:00:00 EST 1994 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1897/1552-8618(1994)13[1813:TEOETT]2.0.CO;2· OSTI ID:7099422

Brauner, C J; Randall, D J ^[1]; Neuman, J F; Thurston, R V ^[2]

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1. Univ. of British Columbia, Vancouver, British Columbia (Canada). Dept. of Zoology
2. Montana State Univ., Bozeman, MT (United States). Fisheries Bioassay Lab.

These studies were designed to investigate the relationship between the initial uptake of a model toxicant, 1,2,4,5-tetrachlorobenzene (TCB), and the rate of oxygen consumption (MO[sub 2]) in trout during exercise. There was no effect of environmental TCB concentrations ([TCB]) on the MO[sub 2] of resting or exercising adult rainbow trout, and body accumulations of the toxicant did not affect the maximal aerobic swimming velocity attained by juvenile rainbow trout. Rainbow trout were exposed to TCB for 1 h while swimming at different velocities and the [TCB] was measured in plasma and 11 other tissues. Tissue TCB concentrations were found to be extremely variable despite similar exposure conditions, likely due to differences in tissue lipid content. No one tissue was representative of body burden, but tissue TCB delivery appears to be directly related to the [TCB] in the plasma because at different swimming velocities the plasma:tissue TCB ratios remained constant despite regional changes in blood flow. After 2 h of TCB exposure, [TCB] in the plasma was equal to whole-body [TCB]; however, this relationship broke down after 6 h. Thus, whole-body TCB concentrations can only be obtained through direct measurement. There was a highly significant relationship between MO[sub 2] and TCB uptake rate during initial toxicant exposure in adult rainbow trout forced to swim over a large proportion of its aerobic potential. Thus, toxicant uptake in fish may be estimated based upon MO[sub 2], which can be measured or can be obtained from the literature.

• OSTI ID: 7099422
• Journal Information: Environmental Toxicology and Chemistry; (United States), Vol. 13:11; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
TISSUE DISTRIBUTION
TOXICITY
OXYGEN
UPTAKE
TROUT
SENSITIVITY
ANIMALS
AQUATIC ORGANISMS
AROMATICS
DISTRIBUTION
ELEMENTS
FISHES
HALOGENATED AROMATIC HYDROCARBONS
NONMETALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology