Comparative study of the tissue distribution of NADH and NADPH-dependent chloral hydrate reducing enzymes in the rat

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701218· OSTI ID:7098759

Ogino, Keiki; Hobara, Tatsuya; Kobayashi, Haruo; Iwamoto, Susumu ^[1]

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1. Yamaguchi Univ. School of Medicine, Kogushi Ube (Japan)

Chloral hydrate (CH), an intermediate metabolite of trichloroethylene, is reduced to trichloroethanol (TCE) by alcohol dehydrogenase and aldehyde reductase. Alcohol dehydrogenase requires reduced nicotinamide adenine dinucleotide (NADH), and aldehyde reductase requires reduced nicotinamide adenine dinucleotide phosphate (NADPH). No reports have appeared concerning comparative studies of the tissue distribution of CH-reducing enzymes. In this report, NADH and NADPH-dependent CH-reducing activities were investigated in various organs of the rat.

• OSTI ID: 7098759
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:3; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED ALIPHATIC HYDROCARBONS
METABOLISM
HEMIACETAL DEHYDROGENASES
TISSUE DISTRIBUTION
ADRENAL GLANDS
HYDRATES
INTESTINES
KIDNEYS
LIVER
LUNGS
NADH2
NADP
RATS
ANIMALS
BODY
COENZYMES
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
NUCLEOTIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology