skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing

Abstract

The healing process of cysteamine-induced duodenal ulcer was studied by (/sup 3/H)thymidine autoradiography. After the development of ulcer in the duodenum, cell proliferation was markedly activated not only in the crypts but also in the Brunner's glands near the ulcer. In the initial stages of ulcer healing, they both contributed to form the surface covering regenerating epithelium. Granulation tissue also proliferated at the base of the ulcer. In later stages of ulcer healing, new crypts were formed in the floor of the ulcer. New villi regenerated from these crypts and Brunner's glands regenerated by proliferation in situ. The ulcer base then was completely covered with new villi and granulation tissue was replaced by dense fibrous connective tissue. The present study suggested that the Brunner's glands, together with the crypts of Lieberkuehn, play an important role in the healing process of cysteamine-induced duodenal ulcer.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Kyoto Prefectural Univ. of Medicine (Japan)
OSTI Identifier:
7092865
Resource Type:
Journal Article
Journal Name:
Dig. Dis. Sci.; (United States)
Additional Journal Information:
Journal Volume: 33:9
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; EPITHELIUM; CELL PROLIFERATION; SMALL INTESTINE; ULCERS; HEALING; AUTORADIOGRAPHY; RATS; THYMIDINE; TRITIUM COMPOUNDS; ANIMAL TISSUES; ANIMALS; AZINES; BIOLOGICAL RECOVERY; BODY; DIGESTIVE SYSTEM; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; INTESTINES; LABELLED COMPOUNDS; MAMMALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PYRIMIDINES; RECOVERY; RIBOSIDES; RODENTS; TISSUES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Fuse, Y., Tsuchihashi, Y., Sugihara, H., Kodama, T., Takino, T., and Fujita, S. Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing. United States: N. p., 1988. Web. doi:10.1007/BF01535782.
Fuse, Y., Tsuchihashi, Y., Sugihara, H., Kodama, T., Takino, T., & Fujita, S. Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing. United States. doi:10.1007/BF01535782.
Fuse, Y., Tsuchihashi, Y., Sugihara, H., Kodama, T., Takino, T., and Fujita, S. Thu . "Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing". United States. doi:10.1007/BF01535782.
@article{osti_7092865,
title = {Autoradiographic study on healing process of cysteamine-induced duodenal ulcer in rat. Possible importance of Brunner's glands in ulcer healing},
author = {Fuse, Y. and Tsuchihashi, Y. and Sugihara, H. and Kodama, T. and Takino, T. and Fujita, S.},
abstractNote = {The healing process of cysteamine-induced duodenal ulcer was studied by (/sup 3/H)thymidine autoradiography. After the development of ulcer in the duodenum, cell proliferation was markedly activated not only in the crypts but also in the Brunner's glands near the ulcer. In the initial stages of ulcer healing, they both contributed to form the surface covering regenerating epithelium. Granulation tissue also proliferated at the base of the ulcer. In later stages of ulcer healing, new crypts were formed in the floor of the ulcer. New villi regenerated from these crypts and Brunner's glands regenerated by proliferation in situ. The ulcer base then was completely covered with new villi and granulation tissue was replaced by dense fibrous connective tissue. The present study suggested that the Brunner's glands, together with the crypts of Lieberkuehn, play an important role in the healing process of cysteamine-induced duodenal ulcer.},
doi = {10.1007/BF01535782},
journal = {Dig. Dis. Sci.; (United States)},
number = ,
volume = 33:9,
place = {United States},
year = {1988},
month = {9}
}