Differences in response of glucuronide and glutathione conjugating enzymes to aflatoxin B/sub 1/ and N-acetylaminofluorene in underfed rats
Changes in the hepatic drug/xenobiotic-metabolizing enzymes in underfed rats exposed to aflatoxin B/sub 1/ and N-acetylaminofluorene were investigated. Neither carcinogen, fed at the level of 10 ..mu..g and 0.667 mg per 100 g body weight, respectively, over a period of 3 wk, had any significant influence on cytochrome P-450 and aryl hydrocarbon hydroxylase in the undernourished rats. Significantly low activities of UDP-glucuronyltransferase and glutathione S-transferase were observed in food-restricted animals fed on aflatoxin B/sub 1/. N-acetylaminofluorene, on the other hand stimulated both the enzyme activities in the underfed group, to as much observed in the respective well-fed treated group. UDP-Glucuronyltransferase and glutathione S-transferase in undernutrition seem to respond differently to aflatoxin B/sub 1/ and N-acetylaminofluorene. Further studies are needed to assess the possible consequences of such alterations.
- Research Organization:
- National Institution of Nutrition, Hyderabad (India)
- OSTI ID:
- 7090300
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 24:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACETYLAMINOFLUORENES
TOXICITY
AFLATOXIN
LIVER
ENZYME ACTIVITY
CYTOCHROME OXIDASE
GLUTATHIONE
RATS
TRANSFERASES
ANIMALS
ANTIGENS
BODY
DIGESTIVE SYSTEM
DRUGS
ENZYMES
GLANDS
HAEM DEHYDROGENASES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology