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Title: The human prohibitin (PHB) gene family and its somatic mutations in human tumors

Abstract

Five cosmid clones, isolated by procedures to screen genomic libraries for homologous variants of the human prohibitin gene (PHB), were analyzed to determine their genomic structures. Four of these (PHBP1-4) were found to be processed pseudogenes, each located on a different chromosome from their counter-parts on chromosome 17q21. The DNA sequence of one clone (PHBP1, on chromosome 6q25) shared a 91.3% identity at the nucleotide level with the cDNA of functional prohibitin. A large number of human tumors of the breast, ovary, liver, and lung were examined for somatic mutations in the PHB gene. Although mutations were observed in a few sporadic breast cancers, none were identified in any of the other cancers. 15 refs., 2 figs., 1 tab.

Authors:
; ; ; ; ;  [1]
  1. Cancer Institute, Toshima-ku, Tokyo (Japan)
Publication Date:
OSTI Identifier:
7076454
Resource Type:
Journal Article
Journal Name:
Genomics; (United States)
Additional Journal Information:
Journal Volume: 17:3; Journal ID: ISSN 0888-7543
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; MAMMARY GLANDS; NEOPLASMS; GENE MUTATIONS; DNA SEQUENCING; GROWTH FACTORS; BODY; DISEASES; GLANDS; MITOGENS; MUTATIONS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; STRUCTURAL CHEMICAL ANALYSIS; 550400* - Genetics

Citation Formats

Sato, Takaaki, Sakamoto, Takashi, Takita, Ken-ichi, Saito, Hiroko, Okui, Keiko, and Nakamura, Yusuke. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. United States: N. p., 1993. Web. doi:10.1006/geno.1993.1402.
Sato, Takaaki, Sakamoto, Takashi, Takita, Ken-ichi, Saito, Hiroko, Okui, Keiko, & Nakamura, Yusuke. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. United States. https://doi.org/10.1006/geno.1993.1402
Sato, Takaaki, Sakamoto, Takashi, Takita, Ken-ichi, Saito, Hiroko, Okui, Keiko, and Nakamura, Yusuke. 1993. "The human prohibitin (PHB) gene family and its somatic mutations in human tumors". United States. https://doi.org/10.1006/geno.1993.1402.
@article{osti_7076454,
title = {The human prohibitin (PHB) gene family and its somatic mutations in human tumors},
author = {Sato, Takaaki and Sakamoto, Takashi and Takita, Ken-ichi and Saito, Hiroko and Okui, Keiko and Nakamura, Yusuke},
abstractNote = {Five cosmid clones, isolated by procedures to screen genomic libraries for homologous variants of the human prohibitin gene (PHB), were analyzed to determine their genomic structures. Four of these (PHBP1-4) were found to be processed pseudogenes, each located on a different chromosome from their counter-parts on chromosome 17q21. The DNA sequence of one clone (PHBP1, on chromosome 6q25) shared a 91.3% identity at the nucleotide level with the cDNA of functional prohibitin. A large number of human tumors of the breast, ovary, liver, and lung were examined for somatic mutations in the PHB gene. Although mutations were observed in a few sporadic breast cancers, none were identified in any of the other cancers. 15 refs., 2 figs., 1 tab.},
doi = {10.1006/geno.1993.1402},
url = {https://www.osti.gov/biblio/7076454}, journal = {Genomics; (United States)},
issn = {0888-7543},
number = ,
volume = 17:3,
place = {United States},
year = {Wed Sep 01 00:00:00 EDT 1993},
month = {Wed Sep 01 00:00:00 EDT 1993}
}