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Title: Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]

Abstract

The effects produced by /sup 137/Cs gamma rays delivered at a high (45 rads/min) or intermediate (8.2 rads/day) dose rate and the effect of fission neutrons at a high (25 rads/min) and low (1 rad/day) rate in a population of nearly 30,000 RFM and 11,000 BALB/c mice have been studied. Gamma ray doses ranged from 10 to 400 rads with the RFM's and from 50-400 rads with the BALB/c's, while neutron doses ranged from 5 to 200 rads with both strains. The present paper will present an overview of these data and the general findings while subsequent publications will present detailed analyses of each aspect. A variety of neoplasms were sensitive to induction after radiation exposure, including tumors of both reticular tissue origin (leukemia, lymphoma, etc.) and solid tumors. For the RFM, thymic lymphomas were the dominant reticular tissue neoplasm while the majority of solid tumors were either lung adenomas or fit into the broad category of endocrine related tumors, including ovarian, pituitary, harderian, and uterine tumors. The BALB/c was much less sensitive to induction of reticular tissue neoplasms. The tumors that were most sensitive to induction included malignant lung carcinomas, mammary adenocarcinomas and ovarian tumors. In general for bothmore » life shortening and tumor induction after gamma ray exposures, when the low to intermediate dose range was sufficiently defined, linearity could be rejected and a dose squared or linear-dose squared relationship adequately fit the data. For neutron exposures, on the other hand, linear relationships were the general finding. The RBE for neutrons varied with tumor type and total dose level. For gamma ray irradiation, the intermediate dose rate resulted in a decreased effectiveness in all cases, while for neutron exposures the dose rate relationships were more complex.« less

Authors:
;
Publication Date:
Research Org.:
Oak Ridge National Lab., Tenn. (USA)
OSTI Identifier:
7075670
Report Number(s):
CONF-780306-3
TRN: 78-011034
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Conference
Resource Relation:
Conference: Symposium on late biological effects of ionizing radiation, Vienna, Austria, 13 Mar 1978
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENESIS; RADIOINDUCTION; FISSION NEUTRONS; RBE; LIFE SPAN; BIOLOGICAL RADIATION EFFECTS; NEOPLASMS; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; LUNGS; MAMMARY GLANDS; MICE; OVARIES; RADIATION QUALITY; ANIMALS; BARYONS; BIOLOGICAL EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FEMALE GENITALS; FERMIONS; GLANDS; GONADS; HADRONS; IONIZING RADIATIONS; MAMMALS; NEUTRONS; NUCLEONS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Ullrich, R L, and Storer, J B. Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]. United States: N. p., 1978. Web.
Ullrich, R L, & Storer, J B. Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]. United States.
Ullrich, R L, and Storer, J B. 1978. "Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]". United States. https://www.osti.gov/servlets/purl/7075670.
@article{osti_7075670,
title = {Influence of dose, dose rate, and radiation quality on radiation carcinogenesis and life shortening in RFM and BALB/C mice. [Gamma radiation, fission neutrons]},
author = {Ullrich, R L and Storer, J B},
abstractNote = {The effects produced by /sup 137/Cs gamma rays delivered at a high (45 rads/min) or intermediate (8.2 rads/day) dose rate and the effect of fission neutrons at a high (25 rads/min) and low (1 rad/day) rate in a population of nearly 30,000 RFM and 11,000 BALB/c mice have been studied. Gamma ray doses ranged from 10 to 400 rads with the RFM's and from 50-400 rads with the BALB/c's, while neutron doses ranged from 5 to 200 rads with both strains. The present paper will present an overview of these data and the general findings while subsequent publications will present detailed analyses of each aspect. A variety of neoplasms were sensitive to induction after radiation exposure, including tumors of both reticular tissue origin (leukemia, lymphoma, etc.) and solid tumors. For the RFM, thymic lymphomas were the dominant reticular tissue neoplasm while the majority of solid tumors were either lung adenomas or fit into the broad category of endocrine related tumors, including ovarian, pituitary, harderian, and uterine tumors. The BALB/c was much less sensitive to induction of reticular tissue neoplasms. The tumors that were most sensitive to induction included malignant lung carcinomas, mammary adenocarcinomas and ovarian tumors. In general for both life shortening and tumor induction after gamma ray exposures, when the low to intermediate dose range was sufficiently defined, linearity could be rejected and a dose squared or linear-dose squared relationship adequately fit the data. For neutron exposures, on the other hand, linear relationships were the general finding. The RBE for neutrons varied with tumor type and total dose level. For gamma ray irradiation, the intermediate dose rate resulted in a decreased effectiveness in all cases, while for neutron exposures the dose rate relationships were more complex.},
doi = {},
url = {https://www.osti.gov/biblio/7075670}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1978},
month = {Sun Jan 01 00:00:00 EST 1978}
}

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