Inhibitory effects of a polypeptide thymic factor on the development of 7,12-dimethylbenz(a)anthragene-induced mammary adenocarcinoma in female rats

Journal Article · Tue Jan 01 00:00:00 EST 1980 · Dokl. Biol. Sci. (Engl. Transl.); (United States)

OSTI ID:7064263

Anisimov, V N; Danetskaya, E V; Morozov, V G; Khavinson, V Kh

It has come to be recognized that tumor growth is accompanied by inhibition of cellular immunity and the function of the T lymphocytes. Restitution of T lymphocyte function by means of several pharmacologic agents such as levamisole, phenformin, or epithalamin (an epiphyseal factor) has, in a number of cases, been accompanied by growth inhibition of both spontaneous and induced tumors. In addition, the importance of the thymus in the regulation of T lymphocytes and in antitumor immunity has been recognized. Several indicators point to the fact that the thymus contains physiologically active substances which stimulate T cell-dependent immunity and prevent the occurrence of neoplasms. These considerations have led to attempts at isolation of active thymic factors and studies on their effects on the appearance and growth of tumors. Previously, a thymic factor - thymarin - had been isolated which imparted immunocompetence to the T lymphocytes. This factor differs from other thymic preparations, including thymosine, in terms of a number of physicochemical characteristics and is a polypeptide with a molecular weight of 5000. This study is concerned with its effects on tumor development - mammary gland adenocarcinoma induced in animals with a chemical carcinogen.

• Research Organization: Scientific-Research Inst. of Oncology, Leningrad, USSR
• OSTI ID: 7064263
• Journal Information: Dokl. Biol. Sci. (Engl. Transl.); (United States), Vol. 250:1-6; Other Information: Translated from Dokl. Akad. Nauk SSSR; 250: No. 6, 1485-1487(Jan 1980)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DIMETHYLBENZANTHRACENE
CARCINOGENESIS
THYMUS
IMMUNE REACTIONS
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
CARCINOMAS
IMMUNITY
IMMUNOSUPPRESSION
INHIBITION
LYMPHOCYTES
MAMMARY GLANDS
RESPONSE MODIFYING FACTORS
TUMOR CELLS
ANIMAL CELLS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMISTRY
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DISEASES
GLANDS
KINETICS
LEUKOCYTES
LYMPHATIC SYSTEM
MATERIALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
REACTION KINETICS
SOMATIC CELLS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems
550200 - Biochemistry