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Title: The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36

Abstract

The chromosomal localization of some of the genes participating in the insulin signaling pathway is known. The insulin and insulin receptor genes have been mapped to chromosomes 11 and 19, respectively. To identify the chromosomal localization of the human IRS1 gene, the fluorescence in situ hybridization technique was employed with Genomic Clone B-10. A total of 50 metaphase cells exhibiting either single or double spots of hybridization signals were examined. Among them, 32 showed the specific signals on 2q36. Therefore, the authors assigned the human IRS1 gene to 2q36. The genes for homeobox sequence (HOX4), fibronectin 1, alkaline phosphatase (intestinal), transition protein 1, villin 1, collagen (type IV), Waardenburg syndrome (type 1), alanine-glyoxylate aminotransferase, and glucagon have been localized in the vicinity of the IRS1 gene.

Authors:
; ; ; ;  [1]; ;  [2];  [3];  [4]
  1. (Jikei Univ. School of Medicine, Tokyo (Japan))
  2. (Cancer Institute, Tokyo (Japan))
  3. (Kyoto Prefactural Univ. of Medicine (Japan))
  4. (Harvard Medical School, Boston, MA (United States))
Publication Date:
OSTI Identifier:
7062046
Resource Type:
Journal Article
Journal Name:
Genomics; (United States)
Additional Journal Information:
Journal Volume: 20:1; Journal ID: ISSN 0888-7543
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DIABETES MELLITUS; ETIOLOGY; HUMAN CHROMOSOME 2; GENETIC MAPPING; PHOSPHOTRANSFERASES; CHROMOSOMES; DISEASES; ENDOCRINE DISEASES; ENZYMES; HUMAN CHROMOSOMES; MAPPING; METABOLIC DISEASES; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PROTEINS; TRANSFERASES; 550400* - Genetics

Citation Formats

Nishiyama, Masaki, Matsufuji, Senya, Hayashi, Shin-ichi, Furusaka, Akihiro, Tanaka, Teruji, Inazawa, J., Nakamura, Yusuke, Ariyama, Takeshi, and Wands, J.R. The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36. United States: N. p., 1994. Web. doi:10.1006/geno.1994.1143.
Nishiyama, Masaki, Matsufuji, Senya, Hayashi, Shin-ichi, Furusaka, Akihiro, Tanaka, Teruji, Inazawa, J., Nakamura, Yusuke, Ariyama, Takeshi, & Wands, J.R. The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36. United States. doi:10.1006/geno.1994.1143.
Nishiyama, Masaki, Matsufuji, Senya, Hayashi, Shin-ichi, Furusaka, Akihiro, Tanaka, Teruji, Inazawa, J., Nakamura, Yusuke, Ariyama, Takeshi, and Wands, J.R. Tue . "The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36". United States. doi:10.1006/geno.1994.1143.
@article{osti_7062046,
title = {The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36},
author = {Nishiyama, Masaki and Matsufuji, Senya and Hayashi, Shin-ichi and Furusaka, Akihiro and Tanaka, Teruji and Inazawa, J. and Nakamura, Yusuke and Ariyama, Takeshi and Wands, J.R.},
abstractNote = {The chromosomal localization of some of the genes participating in the insulin signaling pathway is known. The insulin and insulin receptor genes have been mapped to chromosomes 11 and 19, respectively. To identify the chromosomal localization of the human IRS1 gene, the fluorescence in situ hybridization technique was employed with Genomic Clone B-10. A total of 50 metaphase cells exhibiting either single or double spots of hybridization signals were examined. Among them, 32 showed the specific signals on 2q36. Therefore, the authors assigned the human IRS1 gene to 2q36. The genes for homeobox sequence (HOX4), fibronectin 1, alkaline phosphatase (intestinal), transition protein 1, villin 1, collagen (type IV), Waardenburg syndrome (type 1), alanine-glyoxylate aminotransferase, and glucagon have been localized in the vicinity of the IRS1 gene.},
doi = {10.1006/geno.1994.1143},
journal = {Genomics; (United States)},
issn = {0888-7543},
number = ,
volume = 20:1,
place = {United States},
year = {1994},
month = {3}
}