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Title: Kidney disease in beagles injected with polonium-210

Abstract

An unusually high incidence of kidney disease (tubular degeneration and necrosis with fibrous replacement) was observed among 24 beagles injected at about 5 years of age with 116 or 329 kBq 226Ra kg-1 but not among an additional 10 beagles given about 39 kBq 226Ra kg-1. This 226Ra solution also contained 210Pb, 210Bi, and 210Po. To determine whether the kidney disease was related to the radiation from 226Ra and its short-lived progeny or to the alpha radiation from 210Po, 2 beagles about 7 years of age were injected with 451 kBq 226Ra kg-1 of 210Po citrate. Measurements of polonium retention in the kidneys of 4 additional beagles given 210Bi citrate enabled us to model the retention of these emitters in the dog kidney and to estimate the kidney dose from the alpha radiation of 210Po following injection of either 226Ra + 210Bi + 210Po or 210Po only. Autoradiography revealed that almost equal concentrations of 210Po were in the tubular epithelium and/or its basement membrane and in the glomeruli, but very little of the 210Bi deposited in kidney tissue was present in the glomeruli. Radiation damage to the kidneys similar to that observed previously in beagles given 226Ra solutions that alsomore » contained 210Bi and 210Po was seen among the beagles given 210Po but not in the dogs given purified 226Ra. The analysis of these data indicated that the relatively high incidence of kidney disease among the mature beagles injected with 226Ra and its accompanying 210Bi and 210Po resulted from alpha irradiation of the kidneys by the substantial amount of 210Po that was in the injection solution.« less

Authors:
; ; ; ;  [1]
  1. Univ. of Utah School of Medicine, Salt Lake City (USA)
Publication Date:
OSTI Identifier:
7062000
Resource Type:
Journal Article
Journal Name:
Radiation Research; (USA)
Additional Journal Information:
Journal Volume: 122:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BISMUTH 210; RETENTION; KIDNEYS; RADIONUCLIDE KINETICS; LEAD 210; POLONIUM 210; RADIUM 226; UROGENITAL SYSTEM DISEASES; RADIOINDUCTION; AUTORADIOGRAPHY; BEAGLES; CELL MEMBRANES; RADIATION DOSES; RADIATION INJURIES; ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BISMUTH ISOTOPES; BODY; CARBON 14 DECAY RADIOISOTOPES; CELL CONSTITUENTS; DAYS LIVING RADIOISOTOPES; DISEASES; DOGS; DOSES; EVEN-EVEN NUCLEI; HEAVY ION DECAY RADIOISOTOPES; HEAVY NUCLEI; INJURIES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEAD ISOTOPES; MAMMALS; MEMBRANES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; POLONIUM ISOTOPES; RADIATION EFFECTS; RADIOISOTOPES; RADIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells

Citation Formats

Bruenger, F W, Lloyd, R D, Taylor, G N, Miller, S C, and Mays, C W. Kidney disease in beagles injected with polonium-210. United States: N. p., 1990. Web. doi:10.2307/3577752.
Bruenger, F W, Lloyd, R D, Taylor, G N, Miller, S C, & Mays, C W. Kidney disease in beagles injected with polonium-210. United States. https://doi.org/10.2307/3577752
Bruenger, F W, Lloyd, R D, Taylor, G N, Miller, S C, and Mays, C W. Fri . "Kidney disease in beagles injected with polonium-210". United States. https://doi.org/10.2307/3577752.
@article{osti_7062000,
title = {Kidney disease in beagles injected with polonium-210},
author = {Bruenger, F W and Lloyd, R D and Taylor, G N and Miller, S C and Mays, C W},
abstractNote = {An unusually high incidence of kidney disease (tubular degeneration and necrosis with fibrous replacement) was observed among 24 beagles injected at about 5 years of age with 116 or 329 kBq 226Ra kg-1 but not among an additional 10 beagles given about 39 kBq 226Ra kg-1. This 226Ra solution also contained 210Pb, 210Bi, and 210Po. To determine whether the kidney disease was related to the radiation from 226Ra and its short-lived progeny or to the alpha radiation from 210Po, 2 beagles about 7 years of age were injected with 451 kBq 226Ra kg-1 of 210Po citrate. Measurements of polonium retention in the kidneys of 4 additional beagles given 210Bi citrate enabled us to model the retention of these emitters in the dog kidney and to estimate the kidney dose from the alpha radiation of 210Po following injection of either 226Ra + 210Bi + 210Po or 210Po only. Autoradiography revealed that almost equal concentrations of 210Po were in the tubular epithelium and/or its basement membrane and in the glomeruli, but very little of the 210Bi deposited in kidney tissue was present in the glomeruli. Radiation damage to the kidneys similar to that observed previously in beagles given 226Ra solutions that also contained 210Bi and 210Po was seen among the beagles given 210Po but not in the dogs given purified 226Ra. The analysis of these data indicated that the relatively high incidence of kidney disease among the mature beagles injected with 226Ra and its accompanying 210Bi and 210Po resulted from alpha irradiation of the kidneys by the substantial amount of 210Po that was in the injection solution.},
doi = {10.2307/3577752},
url = {https://www.osti.gov/biblio/7062000}, journal = {Radiation Research; (USA)},
issn = {0033-7587},
number = ,
volume = 122:3,
place = {United States},
year = {1990},
month = {6}
}