Cadmium-109 metabolism in mice. II. Organ retention in mice fed a nutritionally deficient diet during successive rounds of gestation and lactation
- Eastern Washington Univ., Cheney (United States)
- Argonne National Lab., IL (United States)
Organ retention of [sup 109]Cd was studied in multiparous and virgin female mice provided trace amounts of [sup 109]Cd in drinking water and stable Cd as well as certain nutrient minerals, vitamins, and fat all apportioned in solid diet in amounts appropriate for the itai-itai experience. Breeder females maximally experienced 4 non-consecutive rounds of gestation/lactation in a total of 5 such 42-d periods. On a round-by-round basis, breeder organ [sup 109]Cd content and concentration values were compared with those from their time-matched virgin controls. By the end of round 5, most organ [sup 109]Cd content values in breeders were still increasing. Relative to control values at that point, the following increases were observed: whole body (minus gastrointestinal tract), 4.7-fold; mammary tissue, 12.5-fold; liver, 4.7-fold; and kidney, 4.8-fold. Analogous increases in [sup 109]Cd concentration values were mammary tissue, 9.8-fold; liver, 2.8-fold; and kidney, 2.9-fold. Through the five rounds, a temporal shift in fractional Cd distribution was noted for breeder tissues where transfer occurred from those of the mammaries and remaining carcass to kidneys. Although by the end of the period [sup 109]Cd content in the liver still exceeded that in the kindeys, [sup 109]Cd concentration was 4.7-fold greater in renal tissues - an increase not matched by other breeder females consuming nutrient-replete rather than nutrient-deficient (itai-itai) diet. For virgin female mice over the same period, a shift of similar magnitude was observed from remaining carcass to kidneys. Not unlike the breeders, hepatic [sup 109]Cd content again exceeded that in renal tissues, while [sup 109]Cd concentration was 4.5-fold greater in the kidneys. With respect to renal [sup 109]Cd increases, the greater portion of these shifts had occurred by the end of round 3 for both breeder and virgin mice. 13 refs., 1 fig., 3 tabs.
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 7061819
- Journal Information:
- Journal of Toxicology and Environmental Health; (United States), Vol. 38:2; ISSN 0098-4108
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
BIOLOGICAL ACCUMULATION
INGESTION
TOXICITY
FEMALES
LACTATION
NUTRITIONAL DEFICIENCY
PREGNANCY
MICE
BIOLOGICAL EFFECTS
DIET
DIGESTIVE SYSTEM DISEASES
DISTRIBUTION
DRINKING WATER
GASTROINTESTINAL TRACT
KIDNEYS
LIVER
METABOLISM
ORGANS
REPRODUCTIVE DISORDERS
RETENTION
TISSUES
UROGENITAL SYSTEM DISEASES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HYDROGEN COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES
560160* - Radionuclide Effects
Kinetics
& Toxicology
550500 - Metabolism