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Title: Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]

Abstract

Rates of in vitro lipid peroxidation of microsomes and homogenates were found to vary widely among different tissues and species. In rats and rabbits, lung microsomes peroxidized at 25- to 50-fold lower rate than liver, kidney, testes and brain microsomes. Heart microsomes peroxidized at a rate slightly greater than, but most similar to, lung microsomes. Comparison of tissue homogenates also revealed the unique resistance of lung and heart to lipid peroxidation. Higher rates of peroxidation in mouse lung microsomes relative to rabbit, rat and human lung microsomes were similarly correlated with a lower ratio of vitamin E to peroxidizable fatty acids in mouse lung microsomes. These data provide strong support for the role of vitamin E as the major cellular antioxidant, especially in the highly oxygenated tissues of heart and lung, and demonstrate the utility of the microsomal system in characterizing tissue differences in susceptibility to peroxidative membrane decomposition.

Authors:
;
Publication Date:
Research Org.:
Univ. of Rochester, NY
OSTI Identifier:
7060420
Resource Type:
Journal Article
Journal Name:
Lipids; (United States)
Additional Journal Information:
Journal Volume: 15:5
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; ENZYME ACTIVITY; HEART; ANTIOXIDANTS; HOMOGENATES; COMPARATIVE EVALUATIONS; KIDNEYS; LIPIDS; PEROXIDASES; LIVER; LUNGS; MICROSOMES; TESTES; IN VITRO; LIPOSOMES; VITAMIN E; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; ENZYMES; GLANDS; GONADS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; MALE GENITALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANOIDS; ORGANS; OXIDOREDUCTASES; PORPHYRINS; RESPIRATORY SYSTEM; VITAMINS; 550200* - Biochemistry

Citation Formats

Kornbrust, D J, and Mavis, R D. Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]. United States: N. p., 1980. Web.
Kornbrust, D J, & Mavis, R D. Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]. United States.
Kornbrust, D J, and Mavis, R D. 1980. "Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]". United States.
@article{osti_7060420,
title = {Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]},
author = {Kornbrust, D J and Mavis, R D},
abstractNote = {Rates of in vitro lipid peroxidation of microsomes and homogenates were found to vary widely among different tissues and species. In rats and rabbits, lung microsomes peroxidized at 25- to 50-fold lower rate than liver, kidney, testes and brain microsomes. Heart microsomes peroxidized at a rate slightly greater than, but most similar to, lung microsomes. Comparison of tissue homogenates also revealed the unique resistance of lung and heart to lipid peroxidation. Higher rates of peroxidation in mouse lung microsomes relative to rabbit, rat and human lung microsomes were similarly correlated with a lower ratio of vitamin E to peroxidizable fatty acids in mouse lung microsomes. These data provide strong support for the role of vitamin E as the major cellular antioxidant, especially in the highly oxygenated tissues of heart and lung, and demonstrate the utility of the microsomal system in characterizing tissue differences in susceptibility to peroxidative membrane decomposition.},
doi = {},
url = {https://www.osti.gov/biblio/7060420}, journal = {Lipids; (United States)},
number = ,
volume = 15:5,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1980},
month = {Tue Jan 01 00:00:00 EST 1980}
}