Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy

Hinderliter, A L; Adams, Jr, K F; Price, C J; Herbst, M; Koch, G; Sheps, D S

doi:10.1080/00039896.1989.9934381

Title: Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy

Full Record
Other Related Research

Abstract

The effects of acute elevation of carboxyhemoglobin (COHb) concentrations on resting and exercise-induced ventricular arrhythmias were evaluated in 10 patients who had ischemic heart disease and in whom no ectopy during baseline monitoring was noted. After an initial training session, patients were exposed to air, 100 ppm carbon monoxide (CO), or 200 ppm CO on successive days in randomized, double-blind, cross-over fashion. After exposure to 100 and 200 ppm CO, venous COHb levels averaged 4% and 6% respectively. Symptom-limited supine exercise was performed after exposure. Eight of the 10 patients had evidence of exercise-induced ischemia-either angina, 1.0 mm ST depression, or abnormal ejection fraction response-during 1 or more exposure days. Ambulatory electrocardiograms were obtained on each day and analyzed for arrhythmia frequency and severity. On air and CO exposure days, each patient had only 0-1 ventricular premature beat/h in the 2 h prior to exposure, during the exposure period, during the subsequent exercise test, and in the 5 h following the exercise. In conclusion, low-level CO exposure is not arrhythmogenic in patients with coronary artery disease and no ventricular ectopy at baseline.

Authors:

Hinderliter, A L; Adams, Jr, K F; Price, C J; Herbst, M; Koch, G; Sheps, D S ^[1]

Univ. of North Carolina, Chapel Hill (USA)

OSTI Identifier:: 7059191

Resource Type:: Journal Article

Journal Name:: Archives of Environmental Health; (USA)

Additional Journal Information:: Journal Volume: 44:2; Journal ID: ISSN 0003-9896

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARBON MONOXIDE; HEALTH HAZARDS; HEART; BIOLOGICAL FUNCTIONS; CARDIOVASCULAR DISEASES; EXERCISE; PATIENTS; BODY; CARBON COMPOUNDS; CARBON OXIDES; CARDIOVASCULAR SYSTEM; CHALCOGENIDES; DISEASES; FUNCTIONS; HAZARDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; 560300* - Chemicals Metabolism & Toxicology

Citation Formats


                    Hinderliter, A L, Adams, Jr, K F, Price, C J, Herbst, M, Koch, G, and Sheps, D S. Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy.  United States: N. p.,  
        Web.  doi:10.1080/00039896.1989.9934381.

Copy to clipboard


                    Hinderliter, A L, Adams, Jr, K F, Price, C J, Herbst, M, Koch, G, & Sheps, D S. Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy.  United States.  https://doi.org/10.1080/00039896.1989.9934381

Copy to clipboard


                    Hinderliter, A L, Adams, Jr, K F, Price, C J, Herbst, M, Koch, G, and Sheps, D S. .  
        "Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy".  United States.  https://doi.org/10.1080/00039896.1989.9934381.

Copy to clipboard


                    
@article{osti_7059191,

  title        = {Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy},

  author       = {Hinderliter, A L and Adams, Jr, K F and Price, C J and Herbst, M and Koch, G and Sheps, D S},

  abstractNote = {The effects of acute elevation of carboxyhemoglobin (COHb) concentrations on resting and exercise-induced ventricular arrhythmias were evaluated in 10 patients who had ischemic heart disease and in whom no ectopy during baseline monitoring was noted. After an initial training session, patients were exposed to air, 100 ppm carbon monoxide (CO), or 200 ppm CO on successive days in randomized, double-blind, cross-over fashion. After exposure to 100 and 200 ppm CO, venous COHb levels averaged 4% and 6% respectively. Symptom-limited supine exercise was performed after exposure. Eight of the 10 patients had evidence of exercise-induced ischemia-either angina, 1.0 mm ST depression, or abnormal ejection fraction response-during 1 or more exposure days. Ambulatory electrocardiograms were obtained on each day and analyzed for arrhythmia frequency and severity. On air and CO exposure days, each patient had only 0-1 ventricular premature beat/h in the 2 h prior to exposure, during the exposure period, during the subsequent exercise test, and in the 5 h following the exercise. In conclusion, low-level CO exposure is not arrhythmogenic in patients with coronary artery disease and no ventricular ectopy at baseline.},

  doi          = {10.1080/00039896.1989.9934381},

  url          = {https://www.osti.gov/biblio/7059191},
  journal      = {Archives of Environmental Health; (USA)},

  issn         = {0003-9896},

  number       = ,

  volume       = 44:2,

  place        = {United States},

  year         = {},

  month        = {}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1080/00039896.1989.9934381

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Production of arrhythmias by elevated carboxyhemoglobin in patients with coronary artery disease

Journal Article Sheps, D; Herbst, M; Hinderliter, A; ... - Annals of Internal Medicine; (USA)

The object of this study was to assess the effects of exposure to 4% and 6% carboxyhemoglobin on ventricular arrhythmias in patients with coronary artery disease. This was a randomized, double-blind, crossover design. Forty-one nonsmokers with documented coronary artery disease were tested. On day 1, a training session with no exposure, the baseline carboxyhemoglobin level was measured, and a supine bicycle exercise test was done. On days 2 to 4, patients were exposed to room air, 100 ppm carbon monoxide (target, 4% carboxyhemoglobin) or 200 ppm carbon monoxide (target, 6% carboxyhemoglobin), and they then did supine bicycle exercise with radionuclidemore »« less
https://doi.org/10.7326/0003-4819-113-5-343
Carbon monoxide exposure of subjects with documented cardiac arrhythmias

Journal Article Chaitman, B; Dahms, T; Byers, S; ... - Research Report Health Effects Institute; (United States)

The impact of low-level carbon monoxide exposure on ventricular arrhythmia frequency in patients with ischemic heart disease has not been thoroughly studied. The issue is of concern because of the potential proarrhythmic effect of carbon monoxide in patients with ischemic heart disease. We studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. By using appropriate inclusion and exclusion criteria, subjects were selected and enrolled in a randomized double-blind study to determine the effects of carbon monoxide exposure on ventricular arrhythmia frequency at rest,more »« less
Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89

Technical Report Farber, J; Schwartz, P; Vanoli, E; ...

The effect of acute exposure to carbon monoxide on ventricular arrhythmias was studied in dogs with a healed anterior myocardial infarction. The combination of mild exercise and acute myocardial ischemia induces ventricular fibrillation in 60 percent of the animals. Dogs that develop ventricular fibrillation are considered at high risk for sudden death and are defined as susceptible; dogs that survive the test without fatal arrhythmia are considered at low risk and are defined as 'resistant.' The effects of carboxyhemoglobin levels ranging from 5 to 15 percent were tested in resistant and susceptible dogs. A trend toward higher heart rates wasmore »« less
Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991

Technical Report Chaitman, B; Dahms, T; Byers, S; ...

The authors studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. Subjects were selected and enrolled in a randomized double-blind study; the carbon monoxide exposure was designed to result in 3% or 5% carboxyhemoglobin levels, as measured by gas chromatography. Total and repetitive ventricular arrhythmias were measured for four specific time intervals: (1) two hours before carbon monoxide exposure; (2) during the two-hour carbon monoxide exposure; (3) six hours after carbon monoxide exposure; and (4) approximately 10 hours after exposure, or the remainingmore »« less
Left ventricular function in patients with ventricular arrhythmias and aortic valve disease

Journal Article Santinga, J; Kirsh, M; Brady, T; ... - Ann. Thorac. Surg.; (United States)

Forty patients having aortic valve replacement were evaluated preoperatively for ventricular arrhythmia and left ventricular ejection fraction. Arrhythmias were classified as complex or simple using the Lown criteria on the 24-hour ambulatory electrocardiogram; ejection fractions were determined by radionuclide gated blood pool analysis and contrast angiography. The ejection fractions determined by radionuclide angiography were 59.1 +/- 13.1% for 26 patients with simple or no ventricular arrhythmias, and 43.9 +/- 20.3% for 14 patients with complex ventricular arrhythmias (p less than 0.01). Ejection fractions determined by angiography, available for 31 patients, were also lower in patients with complex ventricular arrhythmias (61.1more »« less
https://doi.org/10.1016/S0003-4975(10)61452-X

Similar Records