Metabolic anatomy of paraneoplastic cerebellar degeneration

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410230602· OSTI ID:7039503

Anderson, N E; Posner, J B; Sidtis, J J; Moeller, J R; Strother, S C; Dhawan, V; Rottenberg, D A

Eleven patients with acquired cerebellar degeneration (10 of whom had paraneoplastic cerebellar degeneration (PCD)) were evaluated using neuropsychological tests and /sup 18/F-fluorodeoxyglucose/positron emission tomography to (1) quantify motor, cognitive, and metabolic abnormalities; (2) determine if characteristic alterations in the regional cerebral metabolic rate for glucose (rCMRGlc) are associated with PCD; and (3) correlate behavioral and metabolic measures of disease severity. Eighteen volunteer subjects served as normal controls. Although some PCD neuropsychological test scores were abnormal, these results could not, in general, be dissociated from the effects of dysarthria and ataxia. rCMRGlc was reduced in patients with PCD (versus normal control subjects) in all regions except the brainstem. Analysis of patient and control rCMRGlc data using a mathematical model of regional metabolic interactions revealed two metabolic pattern descriptors, SSF1 and SSF2, which distinguished patients with PCD from normal control subjects; SSF2, which described a metabolic coupling between cerebellum, cuneus, and posterior temporal, lateral frontal, and paracentral cortex, correlated with quantitative indices of cerebellar dysfunction. Our inability to document substantial intellectual impairment in 7 of 10 patients with PCD contrasts with the 50% incidence of dementia in PCD reported by previous investigators. Widespread reductions in PCD rCMRGlc may result from the loss of cerebellar efferents to thalamus and forebrain structures, a reverse cerebellar diaschisis.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY (USA)
• OSTI ID: 7039503
• Journal Information: Ann. Neurol.; (United States), Vol. 23:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
GLUCOSE
METABOLISM
DIAGNOSIS
FLUORINE 18
MATHEMATICAL MODELS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics