Comparison of renal allograft (AG) biopsy diagnosis and temporal quantitation of Tc-99m sulfur colloid (SC) in clinically suspected AG rejection
The purpose of this study was to evaluate the diagnostic efficacy of temporal quantitation of SC compared to tissue diagnosis of AG needle biopsy (Bx). The principal clinical criteria for patient selection were sequential or persistent reduction (at least 40-50%) of AG function as determined by serial serum creatinine levels. Thirty-four AG recipients were examined with SC and subsequent AG Bx in 37 instances. %SC AG accumulation and bone marrow extraction were interpreted in view of the significant sequential of persistent reduction of Ag function. Each AG Bx was collected from multiple needle aspirates and processed for light microscopy and immunoflorescent staining. Bx and SC exam were evaluated for acute rejection (AR), chronic rejection (CR) or other, non-rejection pathology. Acute tissue changes superimposed on chronic were regarded as AR. Acute tissue changes and % SC AG accumulation in the rejection range were graded as mild, moderate and marked. In AR there was 28/28 agreement of Bx and SC diagnosis; of which 7/28 were superimposed on CR. In Cr Bx and SC agreed in 3/7 instances, in 3/7 SC Dx was AR and in 1/7 SC exam was normal. Sensitivity and specificity of the SC diagnosis in this series was 100% and 63% for AR, 43% and 100% for CR and 97% and 100% in all instances of rejection. Bx and SC grading of AR agreed in 64%. In conclusion, temporal quantitation of SC demonstrated overall good correlation with AG Bx diagnosis in this series. The poor sensitivity of 43% of SC in Cr and only 64% correlation in grading AR may be due to inherent Bx sampling and SC data analysis error.
- Research Organization:
- St. Louis VAMC, St. Louis, MO
- OSTI ID:
- 7030229
- Report Number(s):
- CONF-840619-; TRN: 87-010817
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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ANIMAL TISSUES
BIOPSY
RADIOISOTOPE SCANNING
KIDNEYS
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
BONE MARROW CELLS
COLLOIDS
CREATININE
DATA ANALYSIS
DIAGNOSTIC USES
ERRORS
EXTRACTION
LABELLING
MICROSCOPY
PATIENTS
SAMPLING
SENSITIVITY
SULFUR
TECHNETIUM 99
TRACER TECHNIQUES
ANIMAL CELLS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
ELEMENTS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
SEPARATION PROCESSES
SOMATIC CELLS
TECHNETIUM ISOTOPES
TISSUES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics