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Title: Infectivity model verification studies, annual report - 1981

Abstract

The infectivity model has been used as one of the leading indicators of the potential health effects that may be associated with energy-related pollutants including nitrogen dioxide (NOs), ozone, and diesel exhaust. The original studies with the infectivity model and chronic exposure to NO2 reported by Ehrlich and Henry (1968) have not been replicated. This report details the work that has been performed in Texas Tech's laboratory thus far in initiating a chronic NO2 exposure study to replicate the original work by Ehrlich and Henry, and reviews the preliminary results. At the end of the first contract year, a functioning inhalation facility with a capability to expose animals continuously to low levels of NO2 is in place. One group of animals has been exposed to NO2 for eight months and challenged with Klebsiella pneumonia by inhalation. The results are similar to, but do not replicate entirely, those reported by Ehrlich and Henry. Two additional exposures have been initiated, and the animals will be challenged with the infectious agent in a bacterial infectivity chamber similar to that used by EPA.

Authors:
Publication Date:
Research Org.:
Texas Tech Univ., Lubbock (USA). Dept. of Physiology
OSTI Identifier:
7028596
Alternate Identifier(s):
OSTI ID: 7028596
Report Number(s):
PB-82-194127
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 54 ENVIRONMENTAL SCIENCES; EXHAUST GASES; BIOLOGICAL EFFECTS; LABORATORY ANIMALS; IMMUNITY; NITROGEN DIOXIDE; OZONE; AEROSOLS; AIR POLLUTION; BACTERIA; CHRONIC EXPOSURE; EXPOSURE CHAMBERS; HEALTH HAZARDS; INFECTIOUS DISEASES; INHALATION; RESPIRATORY SYSTEM; SAMPLING; CHALCOGENIDES; COLLOIDS; DISEASES; DISPERSIONS; FLUIDS; GASEOUS WASTES; GASES; HAZARDS; INTAKE; MICROORGANISMS; NITROGEN COMPOUNDS; NITROGEN OXIDES; OXIDES; OXYGEN COMPOUNDS; POLLUTION; SOLS; WASTES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987); 500200 -- Environment, Atmospheric-- Chemicals Monitoring & Transport-- (-1989)

Citation Formats

McGrath, J.J. Infectivity model verification studies, annual report - 1981. United States: N. p., 1982. Web.
McGrath, J.J. Infectivity model verification studies, annual report - 1981. United States.
McGrath, J.J. Fri . "Infectivity model verification studies, annual report - 1981". United States. doi:.
@article{osti_7028596,
title = {Infectivity model verification studies, annual report - 1981},
author = {McGrath, J.J.},
abstractNote = {The infectivity model has been used as one of the leading indicators of the potential health effects that may be associated with energy-related pollutants including nitrogen dioxide (NOs), ozone, and diesel exhaust. The original studies with the infectivity model and chronic exposure to NO2 reported by Ehrlich and Henry (1968) have not been replicated. This report details the work that has been performed in Texas Tech's laboratory thus far in initiating a chronic NO2 exposure study to replicate the original work by Ehrlich and Henry, and reviews the preliminary results. At the end of the first contract year, a functioning inhalation facility with a capability to expose animals continuously to low levels of NO2 is in place. One group of animals has been exposed to NO2 for eight months and challenged with Klebsiella pneumonia by inhalation. The results are similar to, but do not replicate entirely, those reported by Ehrlich and Henry. Two additional exposures have been initiated, and the animals will be challenged with the infectious agent in a bacterial infectivity chamber similar to that used by EPA.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1982},
month = {Fri Jan 01 00:00:00 EST 1982}
}

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