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Title: Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation

Abstract

We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia maymore » play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.« less

Authors:
; ; ; ; ; ; ; ;  [1]
  1. Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City (Mexico)
Publication Date:
OSTI Identifier:
7021533
Resource Type:
Journal Article
Journal Name:
Chest; (United States)
Additional Journal Information:
Journal Volume: 103:1; Journal ID: ISSN 0012-3692
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INDOOR AIR POLLUTION; CHRONIC EXPOSURE; WOMEN; RESPIRATORY SYSTEM DISEASES; WOOD BURNING APPLIANCES; SMOKES; BLOOD PRESSURE; BRONCHITIS; HYPERTENSION; INHALATION; LUNGS; AEROSOLS; AIR POLLUTION; ANIMALS; APPLIANCES; BODY; CARDIOVASCULAR DISEASES; COLLOIDS; DISEASES; DISPERSIONS; EQUIPMENT; FEMALES; INTAKE; MAMMALS; MAN; ORGANS; POLLUTION; PRIMATES; RESIDUES; RESPIRATORY SYSTEM; SOLS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 550900* - Pathology; 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Sandoval, J, Salas, J, Martinez-Guerra, M L, Gomez, A, Martinez, C, Portales, A, Palomar, A, Villegas, M, and Barrios, R. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation. United States: N. p., 1993. Web. doi:10.1378/chest.103.1.12.
Sandoval, J, Salas, J, Martinez-Guerra, M L, Gomez, A, Martinez, C, Portales, A, Palomar, A, Villegas, M, & Barrios, R. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation. United States. doi:10.1378/chest.103.1.12.
Sandoval, J, Salas, J, Martinez-Guerra, M L, Gomez, A, Martinez, C, Portales, A, Palomar, A, Villegas, M, and Barrios, R. Fri . "Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation". United States. doi:10.1378/chest.103.1.12.
@article{osti_7021533,
title = {Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation},
author = {Sandoval, J and Salas, J and Martinez-Guerra, M L and Gomez, A and Martinez, C and Portales, A and Palomar, A and Villegas, M and Barrios, R},
abstractNote = {We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia may play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.},
doi = {10.1378/chest.103.1.12},
journal = {Chest; (United States)},
issn = {0012-3692},
number = ,
volume = 103:1,
place = {United States},
year = {1993},
month = {1}
}