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Title: Experimental drug-induced changes in renal function and biodistribution of /sup 99m/Tc-MDP

Abstract

Increased renal uptake of /sup 99m/Tc methylene diphosphonate (MDP) was observed irregularly in rats after methotrexate, vincristine or gentamicin, administered separately. Cisplatin regularly induced a dose-related increased MDP uptake which correlated with the degree of tubular damage histologically. The augmented MDP renal uptake was not consistently accompanied by a decreased clearance of simultaneously injected I-131 Hippuran, particularly at lower drug dose levels. This observation agreed with previous evidence that the mechanisms of tubular transport of diphosphonates and organic acids like Hippuran are different. At higher dose levels, the augmented MDP uptake was accompanied by increased renal calcium, hypophosphatemia, elevated serum urea nitrogen and creatinine, and only occasional, mild hypercalcemia. The magnitude of the increased renal uptake of MDP observed could not be explained by alterations in iron metabolism or by dehydration. Drug-induced renal retention of MDP by a factor of 2 or more above normal appears to be a useful indicator of tubular damage when other parameters of renal function are sometimes normal.

Authors:
; ; ; ; ; ; ;
Research Org.:
State Univ. of New York, Syracuse
OSTI Identifier:
7013690
Resource Type:
Journal Article
Resource Relation:
Journal Name: Invest. Radiol.; (United States); Journal Volume: 18:5
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTINEOPLASTIC DRUGS; BIOLOGICAL EFFECTS; PHOSPHONATES; RENAL CLEARANCE; TECHNETIUM 99; UPTAKE; IODINE 131; LABELLED COMPOUNDS; RATS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CLEARANCE; DAYS LIVING RADIOISOTOPES; DRUGS; EXCRETION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

McAfee, J.G., Singh, A., Roskopf, M., Ritter, C., Lyons, B., Schoonmaker, J.E., Thomas, F.D., and Jones, D.. Experimental drug-induced changes in renal function and biodistribution of /sup 99m/Tc-MDP. United States: N. p., Web.
McAfee, J.G., Singh, A., Roskopf, M., Ritter, C., Lyons, B., Schoonmaker, J.E., Thomas, F.D., & Jones, D.. Experimental drug-induced changes in renal function and biodistribution of /sup 99m/Tc-MDP. United States.
McAfee, J.G., Singh, A., Roskopf, M., Ritter, C., Lyons, B., Schoonmaker, J.E., Thomas, F.D., and Jones, D.. . "Experimental drug-induced changes in renal function and biodistribution of /sup 99m/Tc-MDP". United States.
@article{osti_7013690,
title = {Experimental drug-induced changes in renal function and biodistribution of /sup 99m/Tc-MDP},
author = {McAfee, J.G. and Singh, A. and Roskopf, M. and Ritter, C. and Lyons, B. and Schoonmaker, J.E. and Thomas, F.D. and Jones, D.},
abstractNote = {Increased renal uptake of /sup 99m/Tc methylene diphosphonate (MDP) was observed irregularly in rats after methotrexate, vincristine or gentamicin, administered separately. Cisplatin regularly induced a dose-related increased MDP uptake which correlated with the degree of tubular damage histologically. The augmented MDP renal uptake was not consistently accompanied by a decreased clearance of simultaneously injected I-131 Hippuran, particularly at lower drug dose levels. This observation agreed with previous evidence that the mechanisms of tubular transport of diphosphonates and organic acids like Hippuran are different. At higher dose levels, the augmented MDP uptake was accompanied by increased renal calcium, hypophosphatemia, elevated serum urea nitrogen and creatinine, and only occasional, mild hypercalcemia. The magnitude of the increased renal uptake of MDP observed could not be explained by alterations in iron metabolism or by dehydration. Drug-induced renal retention of MDP by a factor of 2 or more above normal appears to be a useful indicator of tubular damage when other parameters of renal function are sometimes normal.},
doi = {},
journal = {Invest. Radiol.; (United States)},
number = ,
volume = 18:5,
place = {United States},
year = {},
month = {}
}