Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract

Journal Article · · J. Agric. Food Chem.; (United States)

DOI:https://doi.org/10.1021/jf00061a007· OSTI ID:7009641

Safe, S; Safe, L; Mullin, M

On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6-,2,2',4,4',5,5'-, 2,2',3,4,5,5'-, and 2,2',3,4,4',5'-haxachlorobiphenyl and 2,2',3,3',4,4',5-, 2,2'3,3'4,5,6'-, 2,2'3,4,4',5,5'-, and 2,2',3,4',5,5',6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri,2,4,4',5-tetra-,2,2',4,4',5-penta-,2,3',4,4',5-penta-,2,2',3,4,4',5'-hexa-,2,2',4,4',5,5'-hexa-,2,2',3,3',4,4',5-hepta-, and 2,2',3,4,4',5-heptachlorobiphenyls. The significance of congener-specific PCB analysis is discussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.

• Research Organization: Texas A and M Univ., College Station
• OSTI ID: 7009641
• Journal Information: J. Agric. Food Chem.; (United States), Vol. 33:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL ACCUMULATION
CHEMICAL ANALYSIS
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
MILK
MAN
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY FLUIDS
FOOD
HALOGENATED AROMATIC HYDROCARBONS
MAMMALS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology