In vivo comparison of 16. cap alpha. -(/sup 77/Br)bromoestradiol-17. beta. and 16. cap alpha. -(/sup 125/I)Iodoestradiol-17. beta
An in vivo comparison of two estrogen-receptor-binding radiopharmaceuticals of high specific activity, 16..cap alpha..-(/sup 77/Br)bromoestradiol-17..beta.. and 16..cap alpha..-(/sup 125/I)iodoestradiol-17..beta.., has been carried out in immature female rats. The iodoestradiol has slightly higher uterine uptake at 1 hr after injection, whereas the brominated analog has significantly enhanced uptake at later times. The similar behavior of the two compounds in vivo suggests that estradiol labeled with I-123, Br-77, or Br-75 could be used interchangeably for the imaging of breast tumors containing estrogen receptors. In addition, coinjection of 16..cap alpha..-(/sup 125/I)iodoestradiol as an internal standard has been shown to be useful for comparison of different radiohalogenated estrogens. 17 references, 4 tables, 1 figure.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- DOE Contract Number:
- AC02-81EV10650
- OSTI ID:
- 7007018
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:5
- Country of Publication:
- United States
- Language:
- English
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16. cap alpha. -(/sup 77/Br)bromoestradiol-17. beta. : a high specific-activity, gamma-emitting tracer with uptake in rat uterus and induced mammary tumors
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Related Subjects
RADIOPHARMACEUTICALS
EVALUATION
ALPHA SOURCES
BETA SOURCES
BROMINE 77
ESTRADIOL
ESTROGENS
IMAGES
IN VIVO
IODINE 125
MAMMARY GLANDS
NEOPLASMS
RATS
RECEPTORS
UTERUS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTRANES
FEMALE GENITALS
GLANDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ION SOURCES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARTICLE SOURCES
RADIATION SOURCES
RADIOISOTOPES
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics