Human papillomavirus type 16 DNA in periungual squamous cell carcinomas

Journal Article · Fri May 12 00:00:00 EDT 1989 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.1989.03420180093037· OSTI ID:7003414

Moy, R L; Eliezri, Y D; Bennett, R G ^[1]; Nuovo, G J; Siverstein, S ^[2]; Zitelli, J A ^[3]

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1. UCLA School of Medicine, Los Angeles, CA (USA)
2. UCLA School of Medicine, Los Angeles, CA (USA) Columbia Univ., New York, NY (USA)
3. Montefiore Hospital, Pittsburgh, PA (USA)

Ten squamous cell carcinomas (in situ or invasive) of the fingernail region were analyzed for the presence of DNA sequences homologous to human papilloma-virus (HPV) by dot blot hybridization. In most patients, the lesions were verrucae of long-term duration that were refractory to conventional treatment methods. Eight of the lesions contained HPV DNA sequences, and in six of these the sequences were related to HPV 16 as deduced from low-stringency nucleic acid hybridization followed by low- and high-stringency washes. Furthermore, the restriction endonuclease digestion pattern of DNA isolated from four of these lesions was diagnostic of episomal HPV 16. The high-frequency association of HPV 16 with periungual squamous cell carcinoma is similar to that reported for HPV 16 with squamous cell carcinomas on mucous membranes at other sites, notably the genital tract. The findings suggest that HPV 16 may play an important role in the development of squamous cell carcinomas of the finger, most notably those lesions that are chronic and located in the periungual area.

• OSTI ID: 7003414
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Vol. 261:18; ISSN 0098-7484
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARCINOMAS
GENETICS
TUMOR CELLS
DNA HYBRIDIZATION
AUTORADIOGRAPHY
DNA
ELECTROPHORESIS
FINGERS
NAILS
ONCOGENIC VIRUSES
PATIENTS
ANIMAL CELLS
BIOLOGY
BODY
BODY AREAS
DISEASES
HANDS
HYBRIDIZATION
LIMBS
MICROORGANISMS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASITES
SKIN
VIRUSES
550200* - Biochemistry