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Title: Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice

Abstract

The study of the times and sequence of neuron formation in various structures of the mammalian brain has made substantial progress thanks to the use of autoradiographic techniques, by which the germinative precursors of neurons can be tagged with tritium-thymidine and the subsequent fate of the labeled cells can be followed. The authors study the space and time sequence of neuron formation and look for the presence of mosaicism of neurogenesis in area CA1 of Ammon's horn of the mouse hippocampus, one of the most regularly arranged hippocampal areas. An analysis of the distribution of intensively labeled neurons in areas CA1 showed the presence of groups of intensively labeled neurons alternating with unlabeled and weakly labeled cells.. Mice receiving tritium-thymidine on the 13th-16th day of embryogenesis were most marked when the isotope was injected on the 14th-15th day of embroygeneisis. The investigation showed that a mosaic pattern of neurogenesis exists in the hippocampus, just as in the neocortex, and it can be regarded as the result of asynchronous production of neurons by local areas of the germinative zone, each of which constructs a radial segment of cortex.

Authors:
;
Publication Date:
Research Org.:
Patrice Lumumba Peoples' Friendship University, Moscow
OSTI Identifier:
6999839
Resource Type:
Journal Article
Journal Name:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
Additional Journal Information:
Journal Volume: 100:9
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; EMBRYONIC CELLS; MITOSIS; MICE; HIPPOCAMPUS; NERVE CELLS; AUTORADIOGRAPHY; CELL PROLIFERATION; GERMINATION; INTRAPERITONEAL INJECTION; LABELLING; MIGRATION; ONTOGENESIS; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMAL CELLS; ANIMALS; AZINES; BODY; BRAIN; CELL DIVISION; CENTRAL NERVOUS SYSTEM; HETEROCYCLIC COMPOUNDS; INJECTION; INTAKE; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RIBOSIDES; RODENTS; SOMATIC CELLS; VERTEBRATES; 550301* - Cytology- Tracer Techniques

Citation Formats

Nazarevskaya, G D, and Reznikov, K Yu. Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice. United States: N. p., 1986. Web.
Nazarevskaya, G D, & Reznikov, K Yu. Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice. United States.
Nazarevskaya, G D, and Reznikov, K Yu. 1986. "Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice". United States.
@article{osti_6999839,
title = {Space and time sequence and mosaicism of neurogenesis in hippocampal area CA1 in mice},
author = {Nazarevskaya, G D and Reznikov, K Yu},
abstractNote = {The study of the times and sequence of neuron formation in various structures of the mammalian brain has made substantial progress thanks to the use of autoradiographic techniques, by which the germinative precursors of neurons can be tagged with tritium-thymidine and the subsequent fate of the labeled cells can be followed. The authors study the space and time sequence of neuron formation and look for the presence of mosaicism of neurogenesis in area CA1 of Ammon's horn of the mouse hippocampus, one of the most regularly arranged hippocampal areas. An analysis of the distribution of intensively labeled neurons in areas CA1 showed the presence of groups of intensively labeled neurons alternating with unlabeled and weakly labeled cells.. Mice receiving tritium-thymidine on the 13th-16th day of embryogenesis were most marked when the isotope was injected on the 14th-15th day of embroygeneisis. The investigation showed that a mosaic pattern of neurogenesis exists in the hippocampus, just as in the neocortex, and it can be regarded as the result of asynchronous production of neurons by local areas of the germinative zone, each of which constructs a radial segment of cortex.},
doi = {},
url = {https://www.osti.gov/biblio/6999839}, journal = {Bull. Exp. Biol. Med. (Engl. Transl.); (United States)},
number = ,
volume = 100:9,
place = {United States},
year = {Sat Feb 01 00:00:00 EST 1986},
month = {Sat Feb 01 00:00:00 EST 1986}
}