Mouse skin tumor initiation by ionizing radiation and the detection of dominant transforming gene(s)

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:6999194

Jaffe, D R

The initiating potential of a range of 4 MeV X-rays was studied using the mouse skin two-stage model of carcinogenesis. A single dose of radiation was followed by promotion with 12-O-tetradecanoyl phorbol-13-acetate (TPA). The effect of TPA on tumor incidence when applied as a single dose 24 hours prior to irradiation was examined. Studies were also designed to investigate the effect of promotion duration on tumor incidence. Animals were promoted with TPA for 10 to 60 weeks. Evidence presented here indicates that ionizing radiation can act as an initiator in this model system.

• Research Organization: Arizona Univ., Tucson (USA)
• OSTI ID: 6999194
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EXPERIMENTAL NEOPLASMS
RADIOINDUCTION
PHORBOL ESTERS
CARCINOGENESIS
SKIN
X RADIATION
BIOLOGICAL MODELS
DISEASE INCIDENCE
MICE
ANIMALS
BODY
CARCINOGENS
ELECTROMAGNETIC RADIATION
ESTERS
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560300 - Chemicals Metabolism & Toxicology