Relative bioavailability of lead from mining waste soil in rats

Journal Article · Thu Oct 01 00:00:00 EDT 1992 · Fundamental and Applied Toxicology; (United States)

DOI:https://doi.org/10.1016/0272-0590(92)90178-K· OSTI ID:6994844

Freeman, G B; Johnson, J D; Killinger, J M; Liao, S C; Feder, P I; Davis, A O; Ruby, M V; Chaney, R L; Lovre, S C; Bergstrom, P D ^[1]

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1. Battelle, Columbus, OH (United States)

The purposes of this study were to determine the extent of absorption of lead (Pb) in mining waste soil from Butte, Montana, and to investigate the effect of mining waste soil dose (g soil/day) on tissue lead concentrations. Young, 7- to 8-week-old male and female Sprague-Dawley rats (5/sex/group) were given mining waste soil that contained 810 or 3908 ppm lead mixed in a purified diet (AIN-76) at four different dose levels (0.2, 0.5, 2, and 5% dietary soil) for 30 consecutive days. Standard groups included untreated controls and dosed feed soluble lead acetate groups (1, 10, 25, 100, and 250 micrograms Pb/g feed). The test soil dose levels bracketed a pica child's soil exposure level and the lead acetate concentrations bracketed the test soil dose levels of lead. Liver, blood, and femur were analyzed for total lead concentration using graphite furnace atomic absorption spectroscopy. Clinical signs, body weight, food consumption, and liver weights for test soil and standard groups were similar to control. Tissue lead concentrations from test soil animals were significantly lower than the tissue concentrations for the lead acetate group. Relative percentage bioavailability values, based on lead acetate as the standard, were independent of the two different test soils, dose levels, and sex and were only slightly dependent on the tissue (blood > bone, liver). Mean relative percentage bioavailability values of lead in the Butte mining waste soil were 20% based on the blood data, 9% based on the bone data, and 8% based on the liver data. The results of this study will provide the information needed to determine the significance of lead exposure from Butte soils in assessing human health risks as part of the Superfund Remedial Investigation/Feasibility Study process.

• OSTI ID: 6994844
• Journal Information: Fundamental and Applied Toxicology; (United States), Vol. 19:3; ISSN 0272-0590
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
LEAD
ABSORPTION
MINERAL WASTES
DOSE-RESPONSE RELATIONSHIPS
RATS
BIOLOGICAL ACCUMULATION
BIOLOGICAL AVAILABILITY
DATA
DOSE RATES
LAND POLLUTION
MINING
MONTANA
PARTICLE SIZE
SOILS
SPECTROSCOPY
TISSUE DISTRIBUTION
ANIMALS
DEVELOPED COUNTRIES
DISTRIBUTION
ELEMENTS
FEDERAL REGION VIII
INFORMATION
MAMMALS
METALS
NORTH AMERICA
POLLUTION
RODENTS
SIZE
SOLID WASTES
SORPTION
USA
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology
540220 - Environment
Terrestrial- Chemicals Monitoring & Transport- (1990-)